ANDROGRAPHOLIDE AND ITS ANALOGUES IN LUNG CANCER

In numerous nations, including India, Andrographis paniculate has been used medicinally in traditional medicine. In addition to having immunosuppressive, antipyretic, analgesic, hepatoprotective, antiviral, and anti-inflammatory effects, andrographolide is one of the key bioactive compounds .Andrographolide and analogs triggered cell cycle arrest, promoted apoptosis in a variety of cancer cells, and showed anticancer effects. In both animal and human cancer cells, andrographolide and analogs produced cell cycle arrest, apoptosis, and reduced metastasis and anti-angiogenesis. Because andrographolide can suppress the activity of v-Src, NF-B, STAT3, and PI3K/AKT as well as impede the advancement of the cell cycle, inflammation, metastasis, and the formation of new blood vessels, these effects are the outcome of the compound. For the development of anticancer drugs, substantial chemical-biological research has been conducted on analogy and andrographolide. In equally in vitro and in vivo representations, several andrographolide analogs consume demonstrated superior anticancer activity. To confirm the pharmacological, pharmaceutical, and toxicological effects of andrographolide, additional clinical and biological investigations are needed.