The origins of strabismus and loss of binocular vision. Implication of the corpus callosum

SummaryStrabismus and loss of binocular vision (BV) are often linked disorders because the parallelism of the eyes is necessary for a proper BV. But no BV may exist in the absence of strabismus. If the question of the consequences of strabismus and loss of BV on the brain has been explored for decades, the core question of their origins is less understood. Strabismus is a developmental disorder which causes are numerous as assessed by the various forms of strabismus. Peripheral causes are sometimes responsible. But central causes are mostly the primum movens of strabismus and loss of BV. Normal interhemispheric callosal connections (CC) being necessary for a proper unification of both visual hemifields and for normal BV along the vertical meridian, we propose here that an abnormal development of the CC might be responsible for strabismus and loss of BV. A misrouting of ganglion cell axons or abnormal development of neuronal activity in the visual system or abnormal development of neuronal activity in the oculomotor system are also proposed to be implicated.ReferenceBui Quoc E, Milleret C. Origins of strabismus and loss of binocular vision. Front Integr Neurosci. 2014 Sep 25;8:71. doi: 10.3389/fnint.2014.00071. eCollection 2014.