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Biomechanical scaffolds of decellularized heart valves modified by electrospun polylactic acid
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Enhancing the mechanical properties and cytocompatibility of
decellularized heart valves is the key to promote the application of
biological heart valves. In order to further improve the mechanical
properties, the electrospinning and non-woven processing methods are
combined to prepare the polylactic acid (PLA)/decellularized heart valve
nanofiber-reinforced sandwich structure electrospun scaffold. The effect
of electrospinning time on the performance of decellularized heart valve
is investigated from the aspects of morphology, mechanical properties,
softness, and biocompatibility of decellularized heart valve. Results of
the mechanical tests show that compared with the pure decellularized
heart valve, the mechanical properties of the composite heart valve were
significantly improved with the tensile strength increasing by 108% and
tensile strain increased by 571% when the electrospinning time exceeded
1 h. In addition, with this electrospinning time, the composite heart
valve has a certain promoting effect on the human umbilical vein
endothelial cells proliferation behavior. This work provides a promising
foundation for tissue heart valve reendothelialization to lay the
groundwork for organoid.
Title: Biomechanical scaffolds of decellularized heart valves modified by electrospun polylactic acid
Description:
Enhancing the mechanical properties and cytocompatibility of
decellularized heart valves is the key to promote the application of
biological heart valves.
In order to further improve the mechanical
properties, the electrospinning and non-woven processing methods are
combined to prepare the polylactic acid (PLA)/decellularized heart valve
nanofiber-reinforced sandwich structure electrospun scaffold.
The effect
of electrospinning time on the performance of decellularized heart valve
is investigated from the aspects of morphology, mechanical properties,
softness, and biocompatibility of decellularized heart valve.
Results of
the mechanical tests show that compared with the pure decellularized
heart valve, the mechanical properties of the composite heart valve were
significantly improved with the tensile strength increasing by 108% and
tensile strain increased by 571% when the electrospinning time exceeded
1 h.
In addition, with this electrospinning time, the composite heart
valve has a certain promoting effect on the human umbilical vein
endothelial cells proliferation behavior.
This work provides a promising
foundation for tissue heart valve reendothelialization to lay the
groundwork for organoid.
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