MO709ASSOCIATION BETWEEN SERUM ELASTIN-DERIVED PEPTIDES AND ABDOMINAL AORTIC CALCIFICATION IN PERITONEAL DIALYSIS PATIENTS: A CROSS-SECTIONAL STUDY

Abstract Background and Aims Peritoneal dialysis (PD) patients experience accelerated arterial aging, which is characterized by elastin degradation. Although elastin-derived peptides (EDPs) have been reported to be associated with vascular diseases, studies on the association between serum EDPs and abdominal aortic calcification (AAC) in PD patients remain limited. Method 126 eligible PD patients were included and first grouped by the presence of AAC by an abdominal computed tomography (CT) scan. Patients with AAC were then grouped into severer and non-severer group according to the annularity of calcification. Logistic regression analysis was conducted to analyze the association between EDPs and AAC or severer AAC. Nomograms were generated to evaluate individualized risk of AAC and severer AAC. Results Serum EDPs were significantly elevated in PD patients compared with healthy controls (interquartile ranges: 37.65-55.02 versus 24.23-39.20 ng/mL; p<0.001), and gradually increased as AAC worsens. Moreover, EDPs had the most excellent discriminatory power to differentiate AAC compared with other mineral metabolism markers. After adjustment for potential variables, higher EDPs were associated with greater risk of developing AAC (Odds ratio: 1.056, 95%CI: 1.010-1.103) and severer AAC (Odds ratio: 1.062, 95%CI: 1.004-1.123). Receiver operating curve analysis (ROC) revealed that a combination of EDPs substantially improved the accuracy of diagnostic performance for AAC and severer AAC. Nomogram demonstrated exceptional ability in recognizing PD patients with susceptibility to AAC or severer AAC. Conclusion Serum EDPs can predict the presence and severity of AAC in PD patients, indicating the possible roles to recognize PD patients at risk for developing AAC and severer AAC.