Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Rat Cartilage Repair Using Nanophase PLGA/HA Composite and Mesenchymal Stem Cells
View through CrossRef
Biodegradable polymer/bioceramic composite poly(lactide- coglycolide)/hydroxyapatite(PLGA/HA) was studied for bone tissue engineering. The PLGA/HA composite was evaluated as a scaffold with the ability for mesenchymal stem cells (MSC) to participate in cartilage repair. The PLGA/HA composite and the PLGA/HA composite cultured with MSC were transplanted into cartilage defects created in rats. The PLGA/HA-MSC and PLGA/HA had better tissue morphology, structure integrity, matrix staining, and much thicker newly formed cartilage than the control group. The histological score for PLGA/ HA-MSC better than that for PLGA/HA; it appears that the MSC plays an important role in tissue repair. Based on these results, using PLGA/HA as the tissue scaffold and the addition of MSC significantly enhances cartilage repair.
Title: Rat Cartilage Repair Using Nanophase PLGA/HA Composite and Mesenchymal Stem Cells
Description:
Biodegradable polymer/bioceramic composite poly(lactide- coglycolide)/hydroxyapatite(PLGA/HA) was studied for bone tissue engineering.
The PLGA/HA composite was evaluated as a scaffold with the ability for mesenchymal stem cells (MSC) to participate in cartilage repair.
The PLGA/HA composite and the PLGA/HA composite cultured with MSC were transplanted into cartilage defects created in rats.
The PLGA/HA-MSC and PLGA/HA had better tissue morphology, structure integrity, matrix staining, and much thicker newly formed cartilage than the control group.
The histological score for PLGA/ HA-MSC better than that for PLGA/HA; it appears that the MSC plays an important role in tissue repair.
Based on these results, using PLGA/HA as the tissue scaffold and the addition of MSC significantly enhances cartilage repair.
Related Results
Karakteristik Poli Asam Laktat Glikolat (Kajian Rasio Asam Laktat Limbah Aren-Asam Glikolat)
Karakteristik Poli Asam Laktat Glikolat (Kajian Rasio Asam Laktat Limbah Aren-Asam Glikolat)
Polimer Poli Asam Laktat Glikolat (PLGA) merupakan salah satu jenis polimer yang telah disetujui FDA dan EMA untuk penggunaan biomedik. Kelebihan PLGA yaitu biokompatibilitas, biod...
Stem cells
Stem cells
What is a stem cell? The term is a combination of ‘cell’ and ‘stem’. A cell is a major category of living thing, while a stem is a site of growth and support for something else. In...
Differential marker expression by cultures rich in mesenchymal stem cells
Differential marker expression by cultures rich in mesenchymal stem cells
AbstractBackgroundMesenchymal stem cells have properties that make them amenable to therapeutic use. However, the acceptance of mesenchymal stem cells in clinical practice requires...
Superior performance of biocomposite nanoparticles PLGA-RES in protecting oocytes against vitrification stimuli
Superior performance of biocomposite nanoparticles PLGA-RES in protecting oocytes against vitrification stimuli
Irreversible cryogenic damage caused by oocyte vitrification limits its widespread use in female fertility preservation. In recent years, nanoparticles (NPs) have gained great atte...
Cu/Gd co-doped hydroxyapatite/PLGA composites enhance MRI imaging and bone defect regeneration
Cu/Gd co-doped hydroxyapatite/PLGA composites enhance MRI imaging and bone defect regeneration
Abstract
Background The hydroxyapatite (HA)/poly(lactide-co-glycolide) acid (PLGA) composite material is one of the most widely used orthopedic implant materials with good ...
Electrospun poly (lactic-co-glycolic acid)/ multiwalled carbon nanotubes composite scaffolds for guided bone tissue regeneration
Electrospun poly (lactic-co-glycolic acid)/ multiwalled carbon nanotubes composite scaffolds for guided bone tissue regeneration
A series of poly (lactic-co-glycolic acid) (PLGA)/multiwalled carbon nanotubes (MWNTs) composite scaffolds was prepared by electrospinning for tissue engineering applications. The ...
An In Situ Gel-Forming Heparin-Conjugated PLGA-PEG-PLGA Copolymer
An In Situ Gel-Forming Heparin-Conjugated PLGA-PEG-PLGA Copolymer
Novel heparin-conjugated PLGA-PEG-PLGA hydrogels were prepared via Michael-type addition between thiolated heparin and PLGA-PEG-PLGA diacrylate. The thiolated heparin (HP-SH) was c...
Therapeutic Effect of Cisplatin-Loaded Polymeric Nanoparticles and Nimotuzumab Combination in Human Glioblastoma Cells
Therapeutic Effect of Cisplatin-Loaded Polymeric Nanoparticles and Nimotuzumab Combination in Human Glioblastoma Cells
Abstract
Objective
This study evaluated the combined therapeutic effects of cisplatin-loaded PEG-PLGA nanoparticles (CIS-PEG-PLGA) and nimotuzumab (NIMO) on glioblastoma (...