Javascript must be enabled to continue!

Lack of Predictive Indices in Kernicterus—Or Lack of Power?

View through CrossRef

Kim et al1 recently reported a case-control study of kernicterus in which they concluded that "analysis of previously suggested risk factors has failed to identify any single factor or combination of factors that could be predictive of the development of kernicterus." Emphasis in their paper was on the lack of statistical significance for most of the factors studied. The value of this study can be increased by providing a measure of the extent to which the lack of statistical significance stems from the (understandably) small sampie size and concomitant lack of statistical power rather than from a true lack of association of the factors with kernicterus.

American Academy of Pediatrics (AAP)

Title: Lack of Predictive Indices in Kernicterus—Or Lack of Power?

Description:

Kim et al1 recently reported a case-control study of kernicterus in which they concluded that "analysis of previously suggested risk factors has failed to identify any single factor or combination of factors that could be predictive of the development of kernicterus.

" Emphasis in their paper was on the lack of statistical significance for most of the factors studied.

The value of this study can be increased by providing a measure of the extent to which the lack of statistical significance stems from the (understandably) small sampie size and concomitant lack of statistical power rather than from a true lack of association of the factors with kernicterus.

Related Results

DIAGNOSIS OF KERNICTERUS IN THE NEONATAL PERIOD

In a series of 882 infants with hemolytic disease of the newborn (erythroblastosis fetalis), 31 infants developed kernicterus. In the neonatal period the diagnosis of kernicterus w...

ecision Farming and Predictive Analytics in Precision Farming and Predictive Analytics in Precision Farming and Predictive Analytics in Precision Farming and Predictive Analytics in Precision Farming and Predictive Analytics in Precision Farming and Predi

The scope of sensor networks and the Internet of Things spanning rapidly to diversified domains but not limited to sports, health, and business trading. In recent past, the sensors...

Kernicterus on the Spectrum

Kernicterus is the potential toxic sequela of extreme neonatal hyperbilirubinemia resulting from the passage of excess free, unconjugated bilirubin across the blood−brain barrier, ...

STUDIES OF NON-HEMOLYTIC HYPERBILIRUBINEMIA IN PREMATURE INFANTS

1. A prospective clinical study of nonhemolytic hyperbilirubinemia in premature infants included 187 infants, of whom 100 had hyperbilirubinemia above 18 mg/100 ml and 87 had bilir...

Causes and Outcome of Neonatal Hyperbilirubinemia in Patiens Admitted in Bacha Khan Medical Complex/Gajju Khan Medical College Swabi

Background: Neonatal hyperbilirubinemia is a common condition affecting a significant proportion of newborns, with potential for severe complications such as kernicterus if not ide...

Constraining simulation uncertainties in a hydrological model of the Congo River Basin including a combined modelling approach for channel-wetland exchanges

Compared to other large river basins of the world, such as the Amazon, the Congo River Basin appears to be the most ungauged and less studied. This is partly because the basin lack...

A Brief Review on Kernicterus

Kernicterus is a rare neurological condition which occurs when the unconjugated bilirubin levels rises above 25 mg/dL in the blood leading to decreased elimination and increased pr...

Kernicterus Reexamined

To the Editor.— Turkel and associates1 postulate that gross bilirubin staining of newborn infants' brains, as observed at autopsy, is only incidental and does not co...