Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Inclusion body myositis, viral infections, and TDP-43: a narrative review
View through CrossRef
AbstractThe ubiquitous RNA-processing molecule TDP-43 is involved in neuromuscular diseases such as inclusion body myositis, a late-onset acquired inflammatory myopathy. TDP-43 solubility and function are disrupted in certain viral infections. Certain viruses, high viremia, co-infections, reactivation of latent viruses, and post-acute expansion of cytotoxic T cells may all contribute to inclusion body myositis, mainly in an age-shaped immune landscape. The virally induced senescent, interferon gamma-producing cytotoxic CD8+ T cells with increased inflammatory, and cytotoxic features are involved in the occurrence of inclusion body myositis in most such cases, in a genetically predisposed host. We discuss the putative mechanisms linking inclusion body myositis, TDP-43, and viral infections untangling the links between viruses, interferon, and neuromuscular degeneration could shed a light on the pathogenesis of the inclusion body myositis and other TDP-43-related neuromuscular diseases, with possible therapeutic implications.
Springer Science and Business Media LLC
Title: Inclusion body myositis, viral infections, and TDP-43: a narrative review
Description:
AbstractThe ubiquitous RNA-processing molecule TDP-43 is involved in neuromuscular diseases such as inclusion body myositis, a late-onset acquired inflammatory myopathy.
TDP-43 solubility and function are disrupted in certain viral infections.
Certain viruses, high viremia, co-infections, reactivation of latent viruses, and post-acute expansion of cytotoxic T cells may all contribute to inclusion body myositis, mainly in an age-shaped immune landscape.
The virally induced senescent, interferon gamma-producing cytotoxic CD8+ T cells with increased inflammatory, and cytotoxic features are involved in the occurrence of inclusion body myositis in most such cases, in a genetically predisposed host.
We discuss the putative mechanisms linking inclusion body myositis, TDP-43, and viral infections untangling the links between viruses, interferon, and neuromuscular degeneration could shed a light on the pathogenesis of the inclusion body myositis and other TDP-43-related neuromuscular diseases, with possible therapeutic implications.
Related Results
Skin TDP-43 pathology as a candidate biomarker for predicting amyotrophic lateral sclerosis decades prior to motor symptom onset
Skin TDP-43 pathology as a candidate biomarker for predicting amyotrophic lateral sclerosis decades prior to motor symptom onset
Abstract
The recognition that disease-associated proteinopathies can manifest in peripheral organs outside the central nervous system preceding the onset of neurolo...
5. All That glitters is not gold
5. All That glitters is not gold
Abstract
Introduction
Inflammatory muscle disease is a rare but well-recognised manifestation of systemic vasculitis. It can pre...
In silico
and
in vitro
studies suggest epigallocatechin gallate (EGCG), a polyphenol in green tea, can bind and modulate the aggregation and cytotoxicity of the full-length TDP-43 protein implicated in
In silico
and
in vitro
studies suggest epigallocatechin gallate (EGCG), a polyphenol in green tea, can bind and modulate the aggregation and cytotoxicity of the full-length TDP-43 protein implicated in
ABSTRACT
Misfolding and aggregation of TDP-43 protein are implicated in several proteinopathies like ALS and FTLD. Extracellular TDP-43 is also p...
Tijelo u opusu Janka Polića Kamova
Tijelo u opusu Janka Polića Kamova
The doctoral disertation is dedicated to the concept of the body in the works of Janko Polić Kamov. The body is approached as a signifier system on the basis of which numerous and ...
Metagenome-wide Association Study of Gut Microbiome Features for Myositis
Metagenome-wide Association Study of Gut Microbiome Features for Myositis
Abstract
Background: The clinical relevance and pathogenic role of gut microbiome in both myositis and its associated interstitial lung disease (ILD) are still unclear.The ...
Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration
Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration
Abstract
TDP-43 is mislocalized from the nucleus and aggregates within the cytoplasm of affected neurons in cases of amyotrophic lateral sclerosis. TDP-43 pathology ...
RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy
RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy
Abstract
TDP-43 proteinopathies including frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized...
RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy
RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy
Abstract
TDP-43 proteinopathies including frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative diso...