HISTOLOGICAL EFFECT OF SODIUM FLUORIDE AND STANNOUS FLUORIDE GELS ON BUCCAL MUCOSA OF ALBINO RAT

ABSTRACT: Different concentrations of fluoride preparations are being used enormously in dental clinics to prevent dental caries and treat tooth sensitivity. In this study the histological effect of sodium fluoride gel and stannous fluoride gel has been compared on buccal mucosa of albino rats. Material and Methods: This experimental study comprised of 30 Albino rats of average weight 200-250gms which were randomly divided into 3 groups. Out of total 30 rats Control group A was assigned 10 albino rats and rest of the 20 rats were included in experimental groups B and C containing 10 rats each. Animals of group B were topically treated with 0.2% sodium fluoride gel at a dose of 0.5mg/Kg as per body weight on buccal mucosa. The rest of the 10 animals of group C were given 0.4% stannous fluoride gel topically at a dose of 1mg/kg as per bodyweight. Both fluoride gels were applied once daily for 4 minutes with the help of cotton pellet on buccal mucosa for 14 days and were sacrificed on last day under deep anesthesia. Buccal mucosa of each group was taken out for biopsy. The specimens were treated with haematoxylin and eosin stain. Conclusion: Histological analysis showed that sodium fluoride gel has significant toxicity as compared to stannous fluoride gel.