Synthesis of Novel Imidazole Compounds and Evaluation of Their Antimicrobial Activity

Imidazoles are an important class of heterocycles and include many substances of both biological and chemical interest. Insertion of the imidazole nucleus is an important synthetic strategy in drug discovery. Imidazole drugs have broad applications in many areas of clinical medicine. These are currently used as tools in pharmacological studies. The important therapeutic properties of imidazole related drugs have encouraged the medicinal chemists to synthesize and test a large number of novel molecules. In this investigation, it was of interest to synthesize imidazole by refluxing 9, 10-phenenthraquinone with aryl aldehyde, primary amines and ammonium acetate in the presence of glacial acetic acid and a novel series of imidazole derivatives. The structures of the compounds have been established on the basis of spectral analytical data. All the derivatives have been screened for their antimicrobial activities at the 100µg/ml and 200µg/ml against Candida albicans. © 2011 IGJPS. All rights reserved