Correlation Between Carotid Plaque Location And Carotid Blood Flow Dynamics

Abstract Purpose: This study was aimed to investigate the influence of carotid hemodynamics in common carotid artery (CCA) and internal carotid artery (ICA) on carotid plaque location.Methods: A total of 4444 participants from Anhui Maanshan People's Hospital were selected from December 2013 to December 2018. Doppler ultrasound was used to measure the location of carotid plaque. Multiple logistic regression and smooth curve were applied to determine the relationship of carotid plaque location and hemodynamic indexes. Results: Compared with the none plaque group, the ratio of artery systolic and diastolic blood flow velocity in right internal carotid (RICA S/D) was a risk factor for left side plaque group (OR=1.548) after adjustment. Artery systolic and diastolic blood flow velocity ratio of left common carotid artery (LCCA S/D) was a risk factor for right side plaques (OR=1.250). Resistance index of right internal carotid (RICA RI) was a protective factor for bilateral plaques (OR=0.097), while LCCA S/D and RICA S/D were risk factors for bilateral plaques (OR=1.201, OR=1.457). After age stratification, resistance index of right common carotid artery (RCCA RI) and resistance index of left internal carotid artery (LICA RI) were protective factors for bilateral plaques in groups younger than 52 (OR=0.046, OR=0.042). Artery systolic and diastolic blood flow velocity ratio of right common carotid (RCCA S/D) and RICA S/D were risk factors for bilateral plaques (OR=1.557, OR=1.843). In groups older than 52, RICA S/D was a risk factor for left plaque (OR=1.388). LCCA S/D was a risk factor for right plaque (OR=1.575). LCCA S/D and RICA S/D were risk factors for bilateral plaques (OR=1.348, OR=1.311).Conclusions: In groups younger than 52, the formation of bilateral carotid plaque is associated with low bilateral carotid RI and increased right carotid artery flow rate. In groups older than 52, plaque formation in one carotid artery is associated with high blood flow velocity on the other artery.