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Relationship between Parathyroid hormone and some electrolytes in patients with End-Stage Renal Disease
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parathyroid hormone (PTH) is the main regulator for homeostasis some electrolytes and blood albumin, although the roles of vitamin D3 in the homeostasis of calcium in the bone are well known, However, recent data indicate the existence of the role of vitamin D3 in the Non-bony tissue is through its effect on cell proliferation, differentiation and apoptosis. The vitamin D3 receptor and enzyme 1α-Hydroxylase necessary for the transformation of 25(OH)D3 to 1,25(OH)2D3 and the latter has been disclosed in several tissues, So the 25(OH)D3 may convert into an effective biological status of Paracrine effects and impact on the levels of vitamin D3 in the serum .
The aim of the present study :
evaluate the strength of the link between the PTH levels and some electrolytes in the blood serum of patients with end stage renal disease (ESRD).
evaluate the strength of the link between the vitamin D3 levels and some electrolytes in the blood serum of patients with ESRD.
Identify the natural values of this system, and the changes occurring because of ESRD disease.
Collect samples from venous blood of disease ESRD under Hemodialysis (HD) 106 (60 males, 46 female) patients, and reviewers to the Ibn Sina Centre for dialysis / Baquba teaching Hospital, compared with 48 (32 males 16 females ) blood samples of healthy, with a record age, weight, sex, systolic blood pressure and diastolic blood pressure.
Underwent venous blood samples centrifuge speeds of 4000 r / min for 10 minutes, the serum was separated to perform the following analyzes :-
Measure the level of calcium, phosphate, PTH hormone and vitamin D3 .
The results of the current study:
Increase in the levels of PTH in patients ESRD compared with healthy .
Is not affected the levels of vitamin D3 in the blood serum of patients ESRD significant compared to healthy.
Decrease the levels of calcium in patiets ESRD compared with healthy.
Increase in the levels of phosphate patients ESRD compared to the healthy.
Moreover, study results indicated :
A positive correlation between PTH and phosphate in patients ESRD.
A negative correlation between PTH and calcium, vitamin D3 in patients ESRD.
A positive correlation between vitamin D3 and calcium, phosphate, in patients ESRD
Tikrit University
Title: Relationship between Parathyroid hormone and some electrolytes in patients with End-Stage Renal Disease
Description:
parathyroid hormone (PTH) is the main regulator for homeostasis some electrolytes and blood albumin, although the roles of vitamin D3 in the homeostasis of calcium in the bone are well known, However, recent data indicate the existence of the role of vitamin D3 in the Non-bony tissue is through its effect on cell proliferation, differentiation and apoptosis.
The vitamin D3 receptor and enzyme 1α-Hydroxylase necessary for the transformation of 25(OH)D3 to 1,25(OH)2D3 and the latter has been disclosed in several tissues, So the 25(OH)D3 may convert into an effective biological status of Paracrine effects and impact on the levels of vitamin D3 in the serum .
The aim of the present study :
evaluate the strength of the link between the PTH levels and some electrolytes in the blood serum of patients with end stage renal disease (ESRD).
evaluate the strength of the link between the vitamin D3 levels and some electrolytes in the blood serum of patients with ESRD.
Identify the natural values of this system, and the changes occurring because of ESRD disease.
Collect samples from venous blood of disease ESRD under Hemodialysis (HD) 106 (60 males, 46 female) patients, and reviewers to the Ibn Sina Centre for dialysis / Baquba teaching Hospital, compared with 48 (32 males 16 females ) blood samples of healthy, with a record age, weight, sex, systolic blood pressure and diastolic blood pressure.
Underwent venous blood samples centrifuge speeds of 4000 r / min for 10 minutes, the serum was separated to perform the following analyzes :-
Measure the level of calcium, phosphate, PTH hormone and vitamin D3 .
The results of the current study:
Increase in the levels of PTH in patients ESRD compared with healthy .
Is not affected the levels of vitamin D3 in the blood serum of patients ESRD significant compared to healthy.
Decrease the levels of calcium in patiets ESRD compared with healthy.
Increase in the levels of phosphate patients ESRD compared to the healthy.
Moreover, study results indicated :
A positive correlation between PTH and phosphate in patients ESRD.
A negative correlation between PTH and calcium, vitamin D3 in patients ESRD.
A positive correlation between vitamin D3 and calcium, phosphate, in patients ESRD.
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