Controlled aggregation properties of modified single amino acids

We report the self-assembled structure formed by Fmoc protected charge single amino acid Fmoc-L-glutamic acid 5-tert-butyl ester (Fmoc-Glu(OtBu)-OH), Fmoc-L-aspartic acid 4-tert-butyl ester (Fmoc-Asp(OtBu)-OH), and Na-Fmoc-Ne-Boc-L-lysine (Fmoc-Lys(Boc)-OH). The self-assembled architecture formed by the charge aliphatic amino acids were assessed under different conditions such as concentration, temperature and pH. Fmoc-Glu(OtBu)-OH assembled to spheres at both lower and higher concentration under room temperature condition. However, it forms a broom stick like morphology at both lower and higher concentration on heating. Fmoc-Asp(OtBu)-OH on the other hand formed rod like at both both low and high concentration and also on hhealing. Fmoc-Lys(Boc)-OH also self-assemble to sphere like morphology in all conditions irrespective of concentration and heating. Since these structure are very intriguing, our future endevorous is to study these structure through different microscopic techniques such as scanning electron microscopy (SEM), Transmission Electron microscopy (TEM). The mechanisms of the structure formation by these amino acids will be characterized by using solution state NMR, FTIR and TGA in future. The self-assembled structures formed by modified amino acids are easy and facile route to design novel nanoarchitectures which may be potentially useful in future for various type of applications in the field of material chemistry, bioscience, biomedical.