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Central Nervous System Whipple Disease
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Whipple disease (WD) is a multisystemic infection caused by the bacillus Tropheryma whipplei. Although the organism is ubiquitous in the environment, WD is rare. In affected individuals, the organism resides intracellularly within macrophages and can manipulate host immune responses to avoid clearance. Central nervous system (CNS) involvement can occur as a manifestation of classic WD, in the setting of a relapse of previously treated WD, or rarely as isolated nervous system infection. Diagnosis of CNS WD rests on polymerase chain reaction (PCR) and demonstration of periodic acid-Schiff (PAS) positive macrophages in tissue, and ef
Title: Central Nervous System Whipple Disease
Description:
Whipple disease (WD) is a multisystemic infection caused by the bacillus Tropheryma whipplei.
Although the organism is ubiquitous in the environment, WD is rare.
In affected individuals, the organism resides intracellularly within macrophages and can manipulate host immune responses to avoid clearance.
Central nervous system (CNS) involvement can occur as a manifestation of classic WD, in the setting of a relapse of previously treated WD, or rarely as isolated nervous system infection.
Diagnosis of CNS WD rests on polymerase chain reaction (PCR) and demonstration of periodic acid-Schiff (PAS) positive macrophages in tissue, and ef.
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