Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
In Vitro Anti Sickling Activity of HyphaeneThebaica Fruits Extract on Sickle Cell
View through CrossRef
Abstract
Background: Traditional medicine had been used alongside synthetic pharmaceutical products to enhance health management. Due to the high mortality rate of sickle cell patients, previous studies have been indicated that some medicinal plants have shown an anti-sickling activity, which indicates a new therapeutic way to manage people who are affected by these disorders. The current study aimed to assess in vitro-anti-sickling activity of Hyphaene thebaica (H thebaica) (Doum) fruit. Materials and methods: Blood samples used in the evaluation of the anti-sickling activity of Hyphaene Thebaica Fruits extract in this study was taken from patients known to had Sickle cell disease (HB -SS ) attending the Sickle Cell Clinic in Khartoum state. Emmel test was used to assess anti-sickling activity of this plant. Result: A significant increase in the percentage of unsickled Red blood cells with p-value 0.05 >was observed after incubation of RBCs with 2% sodium metabisulfite in the presence of three different concentration (1000, 500 and 250) μg/ml of Hyphened thebaica for two type of extraction (aqueous and methanol) extract. Conclusion: This study approved that H.thebaica (Doum ) fruit extract had a strong anti- sickling activity ; it could be used for management of sickle cell disease.
Springer Science and Business Media LLC
Title: In Vitro Anti Sickling Activity of HyphaeneThebaica Fruits Extract on Sickle Cell
Description:
Abstract
Background: Traditional medicine had been used alongside synthetic pharmaceutical products to enhance health management.
Due to the high mortality rate of sickle cell patients, previous studies have been indicated that some medicinal plants have shown an anti-sickling activity, which indicates a new therapeutic way to manage people who are affected by these disorders.
The current study aimed to assess in vitro-anti-sickling activity of Hyphaene thebaica (H thebaica) (Doum) fruit.
Materials and methods: Blood samples used in the evaluation of the anti-sickling activity of Hyphaene Thebaica Fruits extract in this study was taken from patients known to had Sickle cell disease (HB -SS ) attending the Sickle Cell Clinic in Khartoum state.
Emmel test was used to assess anti-sickling activity of this plant.
Result: A significant increase in the percentage of unsickled Red blood cells with p-value 0.
05 >was observed after incubation of RBCs with 2% sodium metabisulfite in the presence of three different concentration (1000, 500 and 250) μg/ml of Hyphened thebaica for two type of extraction (aqueous and methanol) extract.
Conclusion: This study approved that H.
thebaica (Doum ) fruit extract had a strong anti- sickling activity ; it could be used for management of sickle cell disease.
Related Results
Allosteric Hemoglobin Effector Loaded Erythrocytes Improve the Efficiency of Transfusion to Prevent Sickling.
Allosteric Hemoglobin Effector Loaded Erythrocytes Improve the Efficiency of Transfusion to Prevent Sickling.
Abstract
Sickle cell disease (SCD) is characterised by abnormal haemoglobin S (HbS). Under hypoxic conditions, HbS crystallizes, inducing sickling of red blood cells...
DISTRIBUTION OF SICKLE CELL ALLELE IN ETHNIC SUB-GROUPS OF THARU IN NEPAL
DISTRIBUTION OF SICKLE CELL ALLELE IN ETHNIC SUB-GROUPS OF THARU IN NEPAL
Sickle cell disease has been a major inherited blood disorder in several populations of the world including Tharu tribal communities of Nepal and India. This cross sectional study ...
Adverse pregnancy, fetal and neonatal outcomes in women with sickle cell disease in a Middle Eastern country
Adverse pregnancy, fetal and neonatal outcomes in women with sickle cell disease in a Middle Eastern country
Background: Sickle cell disease in pregnancy is associated with high maternal and fetal mortality. However, studies reporting pregnancy, fetal, and neonatal outcomes in women with ...
Selected Testing of Newborns for Sickle Cell Disease
Selected Testing of Newborns for Sickle Cell Disease
There are two main reasons for sickle cell testing: the early detection of those with sickle cell disease and the detection of the carrier state, sickle cell trait. The mortality o...
Influence of anti-sickle cell medicinal plants (Carica papaya and Ipomoea batatas) on sickle cell morphology in the Kisangani region
Influence of anti-sickle cell medicinal plants (Carica papaya and Ipomoea batatas) on sickle cell morphology in the Kisangani region
Introduction: This study focused on the influence of presumed anti-sickle cell medicinal plants (Carica papaya and Ipomoea batatas) on sickle cell morphology in the Kisangani regio...
Microalbuminuria among Egyptian Children and Adult with Sickle Cell Hemoglobinopathy, Single Institution Study.
Microalbuminuria among Egyptian Children and Adult with Sickle Cell Hemoglobinopathy, Single Institution Study.
Abstract
Introduction: Renal failure is one of the most serious complications of sickle cell diseases; it affects 5% – 18% and leads to early death. Protienuria is h...
A Scoping Review of Unani Medicinal Herbs Used to Treat Acne Vulgaris
A Scoping Review of Unani Medicinal Herbs Used to Treat Acne Vulgaris
Acne vulgaris (Buthūr Labaniyya) is among the most prevalent dermatological conditions worldwide, often leading to low self-esteem and negatively impacting the quality of life. Con...
Complex Collision Tumors: A Systematic Review
Complex Collision Tumors: A Systematic Review
Abstract
Introduction: A collision tumor consists of two distinct neoplastic components located within the same organ, separated by stromal tissue, without histological intermixing...