Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
In Vitro Anti Sickling Activity of HyphaeneThebaica Fruits Extract on Sickle Cell
View through CrossRef
Abstract
Background: Traditional medicine had been used alongside synthetic pharmaceutical products to enhance health management. Due to the high mortality rate of sickle cell patients, previous studies have been indicated that some medicinal plants have shown an anti-sickling activity, which indicates a new therapeutic way to manage people who are affected by these disorders. The current study aimed to assess in vitro-anti-sickling activity of Hyphaene thebaica (H thebaica) (Doum) fruit. Materials and methods: Blood samples used in the evaluation of the anti-sickling activity of Hyphaene Thebaica Fruits extract in this study was taken from patients known to had Sickle cell disease (HB -SS ) attending the Sickle Cell Clinic in Khartoum state. Emmel test was used to assess anti-sickling activity of this plant. Result: A significant increase in the percentage of unsickled Red blood cells with p-value 0.05 >was observed after incubation of RBCs with 2% sodium metabisulfite in the presence of three different concentration (1000, 500 and 250) μg/ml of Hyphened thebaica for two type of extraction (aqueous and methanol) extract. Conclusion: This study approved that H.thebaica (Doum ) fruit extract had a strong anti- sickling activity ; it could be used for management of sickle cell disease.
Springer Science and Business Media LLC
Title: In Vitro Anti Sickling Activity of HyphaeneThebaica Fruits Extract on Sickle Cell
Description:
Abstract
Background: Traditional medicine had been used alongside synthetic pharmaceutical products to enhance health management.
Due to the high mortality rate of sickle cell patients, previous studies have been indicated that some medicinal plants have shown an anti-sickling activity, which indicates a new therapeutic way to manage people who are affected by these disorders.
The current study aimed to assess in vitro-anti-sickling activity of Hyphaene thebaica (H thebaica) (Doum) fruit.
Materials and methods: Blood samples used in the evaluation of the anti-sickling activity of Hyphaene Thebaica Fruits extract in this study was taken from patients known to had Sickle cell disease (HB -SS ) attending the Sickle Cell Clinic in Khartoum state.
Emmel test was used to assess anti-sickling activity of this plant.
Result: A significant increase in the percentage of unsickled Red blood cells with p-value 0.
05 >was observed after incubation of RBCs with 2% sodium metabisulfite in the presence of three different concentration (1000, 500 and 250) μg/ml of Hyphened thebaica for two type of extraction (aqueous and methanol) extract.
Conclusion: This study approved that H.
thebaica (Doum ) fruit extract had a strong anti- sickling activity ; it could be used for management of sickle cell disease.
Related Results
Allosteric Hemoglobin Effector Loaded Erythrocytes Improve the Efficiency of Transfusion to Prevent Sickling.
Allosteric Hemoglobin Effector Loaded Erythrocytes Improve the Efficiency of Transfusion to Prevent Sickling.
Abstract
Sickle cell disease (SCD) is characterised by abnormal haemoglobin S (HbS). Under hypoxic conditions, HbS crystallizes, inducing sickling of red blood cells...
Adverse pregnancy, fetal and neonatal outcomes in women with sickle cell disease in a Middle Eastern country
Adverse pregnancy, fetal and neonatal outcomes in women with sickle cell disease in a Middle Eastern country
Background: Sickle cell disease in pregnancy is associated with high maternal and fetal mortality. However, studies reporting pregnancy, fetal, and neonatal outcomes in women with ...
Selected Testing of Newborns for Sickle Cell Disease
Selected Testing of Newborns for Sickle Cell Disease
There are two main reasons for sickle cell testing: the early detection of those with sickle cell disease and the detection of the carrier state, sickle cell trait. The mortality o...
Influence of anti-sickle cell medicinal plants (Carica papaya and Ipomoea batatas) on sickle cell morphology in the Kisangani region
Influence of anti-sickle cell medicinal plants (Carica papaya and Ipomoea batatas) on sickle cell morphology in the Kisangani region
Introduction: This study focused on the influence of presumed anti-sickle cell medicinal plants (Carica papaya and Ipomoea batatas) on sickle cell morphology in the Kisangani regio...
Role and Regulation Of Erythrocyte Sphingosine Kinase 1 Activity In Normal and Sickle Cell Disease
Role and Regulation Of Erythrocyte Sphingosine Kinase 1 Activity In Normal and Sickle Cell Disease
Abstract
Sickle Cell Disease (SCD) is a devastating genetic disorder attacking red blood cells (RBCs) and affecting millions of humans worldwide. The Glu/Val mutatio...
Studies on Abnormal Hemoglobins
Studies on Abnormal Hemoglobins
Abstract
1. When sufficiently concentrated sickle cell hemoglobin containing solutions are exposed to a constant stream of CO2 gas, the hemolysates gel. This gelling...
Evaluating the Science to Inform the Physical Activity Guidelines for Americans Midcourse Report
Evaluating the Science to Inform the Physical Activity Guidelines for Americans Midcourse Report
Abstract
The Physical Activity Guidelines for Americans (Guidelines) advises older adults to be as active as possible. Yet, despite the well documented benefits of physical a...
Exchange Transfusion In Adult Patients With Sickle Cell Disease With Refractory Vaso-Occlusive Crises
Exchange Transfusion In Adult Patients With Sickle Cell Disease With Refractory Vaso-Occlusive Crises
Sickle cell disease occurs in 1/500 African-American births. Pain is one of the most common complications of sickle cell disease and is associated with depression, anxiety, decreas...