A STUDY OF SERUM FERRITIN LEVELS IN TYPE 2 DIABETES MELLITUS AND ITS CORRELATION WITH HBA1C LEVELS

Objectives: The etiopathology of type 2 DM is multifactorial. Recently, increased body iron levels have been associated with an increased risk of type 2 DM. Iron through oxidative injury leads to resistant hyperglycaemia and also microvascular diabetic complications. There are few studies which show an association between serum Ferritin and type 2 diabetes mellitus. The present study is conducted to know the association between S.ferritin and DM and correlate Diabetic nephropathy and retinopathy. Methods:50 type 2 DM patients and 50 non-diabetic patients meeting the inclusion criteria were selected from Chalmeda Anand Rao Institute Of Medical Sciences, Karimnagar, Telangana were studied. Necessary Investigations like blood sugars, HbA1c, serum ferritin, urinary Protein and fundoscopy were done. Other relevant investigations were done to exclude patients falling under exclusion Criteria. Results: This study included 50 patients with Type 2 Diabetic Mellitus and 50 controls. The mean Serum Ferritin level is 379.55 mcg/dl in diabetics compared to non-diabetics with mean serum Ferritin of 81.66 mcg/dl. About mean Serum ferritin levels with urinary proteinuria, serum ferritin was 317 mcg/l in diabetic patients with nil urinary protein, 421.43 mcg/l among 1+ urinary protein, 464.37 mcg/l among 2+ urinary protein, 569.02 mcg/l among 3+ urinary protein About Serum ferritin levels with diabetic retinopathy were 319.09 mcg/l in diabetic patients with no fundus changes, 410.02 mcg/l among grade 1 NPDR patients, 529 mcg/l among grade 2 NPDR patients, 543 mcg/l among grade 3 NPDR. Interpretation And Conclusion: This study shows that the level of body iron measured in terms of Serum ferritin is higher in type 2 diabetic patients compared to Non-Diabetics. Diabetic Patients with MicroVascular Complications had higher levels of serum ferritin compared to those without any microvascular complications.