Adiponectin and Lone atrial fibrillation

Objective: Lone atrial fibrillation is an idiopathic arrhythmia seen in younger individuals without any secondary disease. Adiponectin is an endogenous adipocytokine that increases insulin sensitivity with anti-inflammatory and anti-proliferative effects. Although the relationship between circulating adiponectin and atrial fibrillation has been suggested, it is questionable whether this relationship is arrhythmia-related. Therefore, the focus of this study is to investigate the relationship between adiponectin and Lone atrial fibrillation. Methods: In this prospective study, 26 healthy individuals in sinus rhythm, 34 patients with Lone Atrial Fibrillation, and 38 patients diagnosed with Atrial Fibrillation were included by questioning their cardiovascular histories and risk factors upon their arrival at the hospital. Echocardiography was performed to evaluate the left ventricular ejection fraction. Plasma adiponectin levels were studied with Enzyme-Linked ImmunoSorbent Assay (ELISA). Results: Plasma adiponectin levels were significantly lower in the Atrial Fibrillation and Lone Atrial Fibrillation groups compared to the control group (p<0.001, p<0.001). Adiponectin levels did not differ significantly between Atrial Fibrillation and Lone Atrial Fibrillation groups (p=0.191). Furthermore, adiponectin was positively correlated with left ventricular ejection fraction (r=0.208, p=0.04). Conclusion: This study reveals, for the first time, the relationship between plasma adiponectin levels and Lone Atrial Fibrillation. Our results indicated that low adiponectin levels are associated with Lone Atrial Fibrillation and that this relationship persists in patients with secondary Atrial Fibrillation. Therefore, we predict that adiponectin decreases in Atrial Fibrillation due to arrhythmia independent of secondary diseases.