How About Effect of Lithium Carbonate on Preventive Switch Induced by Antidepressants in Patients With Depressive Episode? Chinese Data Analysis

Abstract Background: Although mania or hypomania was defined as indispensable for bipolar disorder, depressive episodes are more common and impairing, with proven response to treatments.So the prevention switch was a important affair in clinical psychiatryMethods: We searched CBM, CNKI, WANFANG and CSSCI in Chinese to find literature from July 1 2000 to July 31 2020 related to the study in model of “comparison of switch rate between combination treatment of lithium and antidepressant and monotherapy of antidepressant in patients with depressive episode”, among which results such as comments, letters, reviews and case reports were excluded. The rate of switch between groups was synthesized and discussed. Result: A total of 695 subjects were included in 9 studies. Random effect model is used to account for the data by Revman 5.2. The results showed that the switch rate of lithium carbonate was 8.28%(29/350),switch rate of antidepressant was 25.29%(87/344), which was very different in switch rate(OR=0.25, 95% CI: 0.16–0.39) and also indicated that lithium reduced switch rate was 67.25%(25.29%-8.28%/25.29%). In bipolar depression group, lithium reduced switch rate was 68.11%(25.84%-8.24%/25.84%). In depression group, lithium reduced switch rate was 67.34%(25.29%-8.26%/25.29%). In group of patients treated by SSRI, lithium reduced switch rate was 60.3%(29.85%-11.85%/29.85%).In group of patients treated by TCA, lithium reduced switch rate was 73.14%(22.28%-6.01%/22.28%). Conclusion: As typical mood stabilizer, lithium carbonate can reduced switch rate related to antidepressant in patients with depressive episode.