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The Recent Report on Schiff Bases and their Complexes as DNA Binders
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Abstract:
Schiff bases are dynamic organic compounds of bioactive importance, acting as
flexible ligands and can form complexes with metals. Schiff bases along with their metal
complexes have shown a large affinity towards DNA, which is one of the main targets of
chemotherapeutics. DNA can join hands with these motifs in multiple ways, like covalent
(crosslinking adducts) and non-covalent (intercalative or groove binding via electrostatic)
interactions. Besides, the binding ability and types vary with the metals involved in Schiff
base metal complexes. Thus, this review aims to describe significant recent reports of Schiff
bases and their metal complexes capable of binding with DNA to evaluate the superlative
DNA binders, type of association, and best metal-Schiff base combinations. Among the experimental
techniques employed in revealing these interactions, noteworthy UV absorption
and fluorescence spectroscopy studies have been discussed for the assessment of various types of bindings as
intercalation or groove type.
Bentham Science Publishers Ltd.
Title: The Recent Report on Schiff Bases and their Complexes as DNA Binders
Description:
Abstract:
Schiff bases are dynamic organic compounds of bioactive importance, acting as
flexible ligands and can form complexes with metals.
Schiff bases along with their metal
complexes have shown a large affinity towards DNA, which is one of the main targets of
chemotherapeutics.
DNA can join hands with these motifs in multiple ways, like covalent
(crosslinking adducts) and non-covalent (intercalative or groove binding via electrostatic)
interactions.
Besides, the binding ability and types vary with the metals involved in Schiff
base metal complexes.
Thus, this review aims to describe significant recent reports of Schiff
bases and their metal complexes capable of binding with DNA to evaluate the superlative
DNA binders, type of association, and best metal-Schiff base combinations.
Among the experimental
techniques employed in revealing these interactions, noteworthy UV absorption
and fluorescence spectroscopy studies have been discussed for the assessment of various types of bindings as
intercalation or groove type.
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