AMELIORATIVE EFFECT OF TRIBULUS TERRESTRIS ON LIVER BIOCHEMICAL PARAMETERS IN ALBINO RAT AFTER TREATMENT WITH DRUG FLUTAMIDE

Chemicals that lessen the harmful effects of hepatotoxic substances on the liver are known as hepatoprotective agents.While some researchers thought of strengthening, tonic, and fortifying. Tribulus terrestris, a leafy herb used in folk medicine, has shown hepatoprotective effects in several studies. The experiment involved the administration of drug toinduce liver damage, followed by treatment with Tribulus terrestris extract. Hepato-biochemical parameters, including serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were monitored to assess liver function and damage. Results showed a significant elevation in ALT, AST and ALP levels in rats treated with flutamide. However, co-administration of Tribulus terrestris extract resulted in a marked reduction in these biochemical parameters, suggesting a protective effect on liver function. The study clearly states that Tribulus terrestris extract exhibits hepatoprotective and effect, mitigating the hepatotoxicity induced by flutamide. These findings suggest that Tribulus terrestris could be considered as a supplementary agent to protect against drug-induced liver damage during long term treatments.