Vitamin D plasma concentration and VDR gene polymorphisms in patients with non-dipper hypertension

Abstract   The study of the effects of vitamin D today has a high interest in the scientific community. We determined the plasma level of vitamin D and the polymorphisms of the vitamin D receptor gene (VDR rs1544410, VDR rs2228570) in patients with non-dipper hypertension. In our clinic, we examined 160 patients aged 30–60, among which a group of hypertensive patients with dipper status included 52 people, a group of hypertensive patients with non-dipper status - 53 people, a control group of 55 people without hypertention, correlating in gender and age with study groups. The 25 OH vitamin D level was lower in the hypertension groups, both dipper status - 20.5 (14.0; 23.3) ng / ml and non-dipper status 15.0 (12.0; 18.0) ng / ml compared with the control group - 26.0 (19.5; 30.5) ng / ml, p=0.003 and p<0.001. The results of genotyping showed the presence of genetic features in hypertensive patients with non-dipper status compared with the hypertensive patients with dipper status and the control group at the rs2228570 locus of the VDR gene, p<0.001. The total frequency of genotypes in the following groups: in the non-dipper group the G / A genotype accounts for 49.1% (26), A/A – 41.5% (22), G/G – 9.4% (5); in the dipper group the G/A genotype was 65.4% (34), A/A – 19.2% (10), G/G – 15.4% (8); in the control group G/A – 47.3% (26), A/A – 10.9% (6), G/G – 41.8% (23) for rs2228570 of the VDR gene. Statistical differences from the dipper group and the control group were not obtained in rs1544410 of the VDR gene. Further studies are needed to clarify the association between rs2228570 of the VDR gene, vitamin D levels and non-dipper status in hypertension. Funding Acknowledgement Type of funding source: None