Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Cardiovascular Safety of Anti-Sclerostin Therapy in Chronic Kidney Disease
View through CrossRef
The significance of sclerostin for bone and cardiovascular health in patients with chronic kidney disease (CKD) is complex and incompletely understood. Experimental evidence suggests that anti-sclerostin therapy shows diminished efficacy on bone in the setting of CKD. Limited clinical evidence suggests that the osteoanabolic and anti-resorptive activity is attenuated, but hypocalcemia is more prevalent in patients with advanced CKD (eGFR < 30 mL/min) treated with anti-sclerostin (romosozumab) therapy as compared to patients without kidney disease. Furthermore, sclerostin is prominently expressed in uremic arteries. Whether the inhibition of sclerostin has adverse effects on cardiovascular health in CKD is currently unknown. This review summarizes the current understanding of the physiology and pathophysiology of sclerostin in CKD, with a focus on the cardiovascular safety of anti-sclerostin therapy in patients with or without CKD.
Title: Cardiovascular Safety of Anti-Sclerostin Therapy in Chronic Kidney Disease
Description:
The significance of sclerostin for bone and cardiovascular health in patients with chronic kidney disease (CKD) is complex and incompletely understood.
Experimental evidence suggests that anti-sclerostin therapy shows diminished efficacy on bone in the setting of CKD.
Limited clinical evidence suggests that the osteoanabolic and anti-resorptive activity is attenuated, but hypocalcemia is more prevalent in patients with advanced CKD (eGFR < 30 mL/min) treated with anti-sclerostin (romosozumab) therapy as compared to patients without kidney disease.
Furthermore, sclerostin is prominently expressed in uremic arteries.
Whether the inhibition of sclerostin has adverse effects on cardiovascular health in CKD is currently unknown.
This review summarizes the current understanding of the physiology and pathophysiology of sclerostin in CKD, with a focus on the cardiovascular safety of anti-sclerostin therapy in patients with or without CKD.
Related Results
Rethinking Anticoagulation in Kidney Disease and Kidney Transplantation
Rethinking Anticoagulation in Kidney Disease and Kidney Transplantation
BackgroundA clinical dilemma exists in patients with CKD, ESKD, and after kidney transplantation, as they face concurrent risks of both thromboembolic and hemorrhagic complications...
Bone Sclerostin and Dickkopf-related protein-1 are positively correlated with bone mineral density, bone microarchitecture, and bone strength in postmenopausal osteoporosis
Bone Sclerostin and Dickkopf-related protein-1 are positively correlated with bone mineral density, bone microarchitecture, and bone strength in postmenopausal osteoporosis
Abstract
Background
Wnt-catenin signaling antagonists sclerostin and dickkopf-related protein-1 (Dkk-1) inhibit bone formation and are involved in t...
The role of sclerostin in the formation of cardiovascular calcifi cation in chronic kidney disease C5D
The role of sclerostin in the formation of cardiovascular calcifi cation in chronic kidney disease C5D
THE AIM: to study the relationship of blood sclerostin with clinical parameters and its influence on the probability of detection of cardiovascular calcification in patients with C...
The Relationship between Sclerostin and Kidney Transplantation Mineral Bone Disorders: A Molecule of Controversies
The Relationship between Sclerostin and Kidney Transplantation Mineral Bone Disorders: A Molecule of Controversies
AbstractKidney transplantation is the most effective treatment option for most patients with end-stage kidney disease due to reduced mortality, decreased cardiovascular events and ...
Relationship between sclerostin and coronary tortuosity in postmenopausal females with non-obstructive coronary artery disease
Relationship between sclerostin and coronary tortuosity in postmenopausal females with non-obstructive coronary artery disease
Abstract
Background
Coronary tortuosity (CT) is commonly encountered in postmenopausal females and is usually present without ob...
Serum sclerostin level in premenopausal women with rheumatoid arthritis: relation to disease activity, fracture risk and bone mineral density
Serum sclerostin level in premenopausal women with rheumatoid arthritis: relation to disease activity, fracture risk and bone mineral density
Abstract
Background
Rheumatoid arthritis (RA) is associated with increased risk of fractures due to decreased bone mass. ...
P1680MINERAL METABOLISM CHANGES AFTER RENAL TRANSPLANTATION
P1680MINERAL METABOLISM CHANGES AFTER RENAL TRANSPLANTATION
Abstract
Background and Aims
Successful renal transplant restores many physiologic abnormalities, including improvement of chron...
MicroRNA-204 may predict the renal function in patients with chronic kidney disease
MicroRNA-204 may predict the renal function in patients with chronic kidney disease
Background:
Chronic kidney disease significantly affects human health by loss of excretory kidney function. MicroRNAs have potential predictive and therapeutic signific...