Javascript must be enabled to continue!
Clinical Outcomes and Predictors of Response for Adalimumab in Patients with Moderately to Severely Active Ulcerative Colitis: A KASID Prospective Multicenter Cohort Study
View through CrossRef
Abstract
A prospective, observational, multicenter study was conducted over 56 weeks in 146 adult patients with moderately to severely active ulcerative colitis (UC) who received adalimumab (ADA) at 17 Korean academic hospitals. Clinical response rates were 52.1% and 37.7% and clinical remission rates were 24.0% and 21.9% at weeks 8 and 56, respectively. Mucosal healing rates were 39.0% and 30.1% at weeks 8 and 56, respectively. Prior use of anti-tumor necrosis factor-α (anti-TNF-α) did not affect clinical outcomes. The ADA drug level was significantly higher in patients with better outcomes at week 8. In patients with lower endoscopic activity, higher body mass index, and higher serum albumin levels at baseline, the clinical response rate was higher at week 8. In patients with lower Mayo scores and C-reactive protein levels, clinical responses, and mucosal healing at week 8, the clinical response rate was higher at week 56. Serious adverse drug reactions were identified in 2.7% of patients. ADA is effective and safe for induction and maintenance in Korean patients with UC, regardless of prior anti-TNF-α therapy. The ADA drug level is associated with the efficacy of induction therapy. Patients with better short-term outcomes were predictive of those with an improved long-term response
Research Square Platform LLC
Seung Yong Shin
Soo Jung Park
Young Kim
Jong Pil Im
Hyo Jong Kim
Kang-Moon Lee
Ji Won Kim
Sung-Ae Jung
Jun Lee
Sang-Bum Kang
Sung Jae Shin
Eun Sun Kim
You Sun Kim
Tae Oh Kim
Hyun-Soo Kim
Dong Il Park
Hyung Kil Kim
Eun Soo Kim
Young-Ho Kim
Do Hyun Kim
Dennis Teng
Jong-Hwa Kim
Wonyong Kim
Chang Hwan Choi
Title: Clinical Outcomes and Predictors of Response for Adalimumab in Patients with Moderately to Severely Active Ulcerative Colitis: A KASID Prospective Multicenter Cohort Study
Description:
Abstract
A prospective, observational, multicenter study was conducted over 56 weeks in 146 adult patients with moderately to severely active ulcerative colitis (UC) who received adalimumab (ADA) at 17 Korean academic hospitals.
Clinical response rates were 52.
1% and 37.
7% and clinical remission rates were 24.
0% and 21.
9% at weeks 8 and 56, respectively.
Mucosal healing rates were 39.
0% and 30.
1% at weeks 8 and 56, respectively.
Prior use of anti-tumor necrosis factor-α (anti-TNF-α) did not affect clinical outcomes.
The ADA drug level was significantly higher in patients with better outcomes at week 8.
In patients with lower endoscopic activity, higher body mass index, and higher serum albumin levels at baseline, the clinical response rate was higher at week 8.
In patients with lower Mayo scores and C-reactive protein levels, clinical responses, and mucosal healing at week 8, the clinical response rate was higher at week 56.
Serious adverse drug reactions were identified in 2.
7% of patients.
ADA is effective and safe for induction and maintenance in Korean patients with UC, regardless of prior anti-TNF-α therapy.
The ADA drug level is associated with the efficacy of induction therapy.
Patients with better short-term outcomes were predictive of those with an improved long-term response.
Related Results
Which innovations can improve timeliness of investigations and address the backlog in endoscopy for patients with potential symptoms of upper and lower Gastrointestinal (GI) cancers?
Which innovations can improve timeliness of investigations and address the backlog in endoscopy for patients with potential symptoms of upper and lower Gastrointestinal (GI) cancers?
TOPLINE SUMMARYWhat is a Rapid Review?Our rapid reviews use a variation of the systematic review approach, abbreviating or omitting some components to generate the evidence to info...
USE OF KRACKOW SUTURES IN PATIENTS WITH LOWER POLE PATELLA FRACTURES:A CLINICAL OUTCOME STUDY
USE OF KRACKOW SUTURES IN PATIENTS WITH LOWER POLE PATELLA FRACTURES:A CLINICAL OUTCOME STUDY
Introduction: Patients with distal pole fractures of the patella have a disrupted extensor mechanism, which results in
considerable functional disability. The ideal method should c...
The Diagnostic Yield of Upper GI Endoscopy in Patients Iron Deficiency Anemia and/or Chronic Diarrhea; With a Special Focus on Celiac Disease
The Diagnostic Yield of Upper GI Endoscopy in Patients Iron Deficiency Anemia and/or Chronic Diarrhea; With a Special Focus on Celiac Disease
Aim of the Study: According to published guidelines, an upper Gastrointestinal (GI) endoscopy with duodenal biopsy sampling should be performed in patients with Iron Deficiency Ane...
Spiculectomy and Orthonyxia for Ingrown Toenails in Patients at Risk; Prospective Observational Cohort Study
Spiculectomy and Orthonyxia for Ingrown Toenails in Patients at Risk; Prospective Observational Cohort Study
Background: Ingrown toenails (unguis incarnatus) are common in persons with Diabetes Mellitus (DM) and Peripheral Arterial Disease (PAD). Minimal invasive treatment of ingrown toen...
Position of the Internal Aperture of Vestibular Aqueduct in Patients With Enlarged Vestibular Aqueduct
Position of the Internal Aperture of Vestibular Aqueduct in Patients With Enlarged Vestibular Aqueduct
Objective:
To investigate the position of the internal aperture of vestibular aqueduct and its relationship to hearing level in patients with enlarged vestibular aquedu...
Comparison of prospective and retrospective motion correction for Magnetic Resonance Imaging of the brain - Master's Thesis in Physics
Comparison of prospective and retrospective motion correction for Magnetic Resonance Imaging of the brain - Master's Thesis in Physics
Head motion is one of the most common sources of artefacts for Magnetic Resonance Imaging (MRI) of the brain. Especially children, being intimidated by the dimensions and the noise...
Presence of Crystals in the Synovial Fluid of Patients With Psoriatic Arthritis
Presence of Crystals in the Synovial Fluid of Patients With Psoriatic Arthritis
Analyzing synovial fluid from joints affected by the pathological process of psoriatic arthritis is part of the overall patient examination, since it may have differential diagnost...
Frequency of Depressive Illness among Caregivers of Drug Addicted Patients
Frequency of Depressive Illness among Caregivers of Drug Addicted Patients
Introduction: Addictions and mental sickness are among the foremost expensive diseases in the world, according to a Worldwide Burden of Illness research, but they often go unnotice...
Recent Results
Modeling Fire Spread in a Real-Time Coupled Atmospheric-Vegetation Fire: An Analytical Approach
Modeling Fire Spread in a Real-Time Coupled Atmospheric-Vegetation Fire: An Analytical Approach
The ability to analyse the rate of fire spread outbreak in a real-time coupled Atmospheric-vegetation fire has become increasingly vital as forest fire fighters are building divers...
Visual art and social structure: the social semiotics of relational art
Visual art and social structure: the social semiotics of relational art
This article elaborates the dialectical relationship between visual art forms and the social structures in which they are produced, by extending Robert Witkin’s taxonomy first pres...