Effect of Menopause and Hypertriglyceridemia on Lipid Transfer and Paraoxonase Activity in Diabetic Women

Introduction. The high prevalence of type 2 diabetes mellitus (DM2) and cardiovascular atherosclerotic complications are increasing in women after menopause. Studies have shown that the in vitro transfer of lipids to HDL and the determination of paraoxonase activity are robust methods to HDL functional evaluation. Objective. This study aimed at observing the difference in the paraoxonase activity and the transfer of lipids to HDL in menopause DM2-women with hypertriglyceridemia. Material and Methods. Blood samples were collected from 63 female diabetic patients with hypertriglyceridemia, matched by age group and comorbidities. The artificial nanoparticle (LDE) determined the transfer to HDL by liquid scintillation, as well the activity of paraoxonase by spectrophotometry. Results. There was a difference in paraoxonase-1 activity between the groups due to the high hypertriglyceridemia, regardless of the menopausal or non-menopausal condition. And, there was also a difference in phospholipid transfer between groups. Discussion. This study showed the presence of alterations in the activity of paraoxonase and phospholipid and cholesterol ester transfer to HDL in menopausal women groups when compared to those non-menopausal groups. Conclusion. This study showed that both diabetic hypertriglyceridemia and menopause influence the HDL metabolism, and the action of paraoxonase.