Design and application of a rate-limiting and precise external cerebrospinal fluid drainage device in patients with carcinomatous meningitis

Abstract Objective To develop a rate-limiting and precise external cerebrospinal fluid drainage device for intracranial decompression in carcinomatous Meningitis (CM). Methods The device consists of an intrathecal drug delivery system (IDDS), a drainage pathway and a pressure measurement pathway. The cerebrospinal fluid pressure (CSF) is measured using the pressure difference between the subarachnoid space and the atmosphere, and the active directional drainage is achieved with the driving force of the infusion pump, and the cerebrospinal fluid pressure is monitored at the same time as the drainage. Results Changed the passive, intermittent and rough drainage of conventional external CSF drainage device to achieve active, continuous, rate-limiting and precise drainage. It was applied to a patient with advanced systemic multiple metastases of gastric indolent cell carcinoma complicated with CM, and the clinical symptoms were well controlled and the intracranial pressure was smoothly controlled for 99 days, without common complications such as high intracranial pressure due to insufficient drainage and low intracranial pressure due to excessive drainage, and without infection, poor drainage and line blockage. Conclusion The device is safe, effective, precise and controllable for drainage of CSF, with good effectiveness, practicality and safety, and is worth promoting.