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Aquaporin-4 facilitator TGN-073 demonstrates novel analgesic activity
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AbstractDuring pre-clinical development, we tested the novel, internally developed AQP-4 facilitator TGN-073 for its effect in a rodent pain model. Therein, TGN-073 was found to exert a strong analgesic effect. Following a single 200 mg/kg (i.p.) administration of TGN-073, a virtually complete block in the acetic acid writhing test was observed. Subsequent in vitro tests demonstrated that TGN-073 had no binding affinity for the μ-opioid or NK-1 receptors. Accordingly, we suspect TGN-073 or other AQP-4 facilitators may be developed into potent non-opioid analgesic agents. Given the potential significance of this discovery, we feel it should be openly shared with the scientific community.
Title: Aquaporin-4 facilitator TGN-073 demonstrates novel analgesic activity
Description:
AbstractDuring pre-clinical development, we tested the novel, internally developed AQP-4 facilitator TGN-073 for its effect in a rodent pain model.
Therein, TGN-073 was found to exert a strong analgesic effect.
Following a single 200 mg/kg (i.
p.
) administration of TGN-073, a virtually complete block in the acetic acid writhing test was observed.
Subsequent in vitro tests demonstrated that TGN-073 had no binding affinity for the μ-opioid or NK-1 receptors.
Accordingly, we suspect TGN-073 or other AQP-4 facilitators may be developed into potent non-opioid analgesic agents.
Given the potential significance of this discovery, we feel it should be openly shared with the scientific community.
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