A Rare Case of Langerhans Cell Histiocytosis in Lynx

Abstract Pulmonary Langerhans cell histiocytosis (PLCH) is a rare neoplastic disease caused by clonal proliferation of Langerhans cells and their associated interstitial lesions in the lungs, which can involve multiple systems, including bone, skin, and lymph nodes, and lead to organ dysfunction. An 8-year-old male lynx in Hohhot Zoo presented clinical manifestations of depression, lethargy, loss of appetite due to lethargy, reduced movement, gradual emaciation, and respiratory distress, over a period of 2 months, before finally dying from exhaustion. Necropsy revealed severe emaciation and dehydration with pleural and abdominal effusions. Based on clinical diagnosis and histopathological features, Lynx confirmed PLCH.According to the literature, this case represented the first report of PLCH in lynx, and this case report should improve our understanding of lynx PLCH and the ability to diagnose and treat it at an early stage.