Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Comparative Study of Flunarizine versus Propranolol in the Prophylaxis of Migraine
View through CrossRef
Background: Propranolol and flunarizine are the most used first-line drugs in the treatment of migraine. There are limited data regarding the use of prophylactic agents available in Bangladesh. This study aimed to compare the efficacy and tolerability of propranolol and flunarizine in prophylactic management. Materials and methods: This was a open label randomized clinical trial. One hundred and fifty migraine patients were recruited from the Outpatient Department of Neurology and Medicine of Chittagong Medical College Hospital from October, 2017 to September, 2018. They were randomized in a 1:1 ratio to receive either flunarizine (n=75) or propranolol (n=75) once daily. Patients were evaluated for attack frequency, pain severity, duration of headache, disability and drug side effects at 6 weeks and 12 weeks. Results: The Flunarizine group showed a reduction in the mean (±SD) frequency of migraine attacks from 10.58±4.11 to 3.25±2.90 per month, intensity of headache per attack from 8.00±1.33 to 3.63±1.87, number of headache days per month from 11.93±4.12 to 3.25±2.90, duration of headache per episode from 21.18±16.15 to 3.13±3.26 and MIDAS (Migraine Disability Assessment Test) score from 23.15±8.77 to 4.70±4.80. In patients treated with propranolol, a reduction in the mean (±SD) of monthly frequency of migraine attacks from 9.64±3.81 to 4.67±3.15, the intensity of headache per attack from 7.99±1.27 to 4.57±1.48, number of headache days per month from 11.66±4.49 to 4.67±3.15, duration of headache per episode from 24.19±19.33 to 4.85±4.31 and MIDAS score from 23.78±10.48 to 6.51±5.36. The percentage of responders at the study endpoint was 58.2% for propranolol and 80.3% for flunarizine. Both the drugs were well tolerated but adverse effects were more in the propranolol group. Conclusion: Flunarizine was more effective and better tolerable than propranolol in prophylaxis of migraine.
Chatt Maa Shi Hosp Med Coll J; Vol.23 (2); July 2024; Page 24-28
Title: Comparative Study of Flunarizine versus Propranolol in the Prophylaxis of Migraine
Description:
Background: Propranolol and flunarizine are the most used first-line drugs in the treatment of migraine.
There are limited data regarding the use of prophylactic agents available in Bangladesh.
This study aimed to compare the efficacy and tolerability of propranolol and flunarizine in prophylactic management.
Materials and methods: This was a open label randomized clinical trial.
One hundred and fifty migraine patients were recruited from the Outpatient Department of Neurology and Medicine of Chittagong Medical College Hospital from October, 2017 to September, 2018.
They were randomized in a 1:1 ratio to receive either flunarizine (n=75) or propranolol (n=75) once daily.
Patients were evaluated for attack frequency, pain severity, duration of headache, disability and drug side effects at 6 weeks and 12 weeks.
Results: The Flunarizine group showed a reduction in the mean (±SD) frequency of migraine attacks from 10.
58±4.
11 to 3.
25±2.
90 per month, intensity of headache per attack from 8.
00±1.
33 to 3.
63±1.
87, number of headache days per month from 11.
93±4.
12 to 3.
25±2.
90, duration of headache per episode from 21.
18±16.
15 to 3.
13±3.
26 and MIDAS (Migraine Disability Assessment Test) score from 23.
15±8.
77 to 4.
70±4.
80.
In patients treated with propranolol, a reduction in the mean (±SD) of monthly frequency of migraine attacks from 9.
64±3.
81 to 4.
67±3.
15, the intensity of headache per attack from 7.
99±1.
27 to 4.
57±1.
48, number of headache days per month from 11.
66±4.
49 to 4.
67±3.
15, duration of headache per episode from 24.
19±19.
33 to 4.
85±4.
31 and MIDAS score from 23.
78±10.
48 to 6.
51±5.
36.
The percentage of responders at the study endpoint was 58.
2% for propranolol and 80.
3% for flunarizine.
Both the drugs were well tolerated but adverse effects were more in the propranolol group.
Conclusion: Flunarizine was more effective and better tolerable than propranolol in prophylaxis of migraine.
Chatt Maa Shi Hosp Med Coll J; Vol.
23 (2); July 2024; Page 24-28.
Related Results
Can smartwatches predict migraines?Using machine learning (ML) with wearable-derived nocturnal autonomic nervous system (ANS) and sleep metrics for headache prediction
Can smartwatches predict migraines?Using machine learning (ML) with wearable-derived nocturnal autonomic nervous system (ANS) and sleep metrics for headache prediction
Abstract
Objective
To investigate whether nocturnal autonomic nervous system (ANS) activity and sleep metrics, as measured by a wearable device, can predict the occ...
MRI radiomics based machine learning model of the periaqueductal gray matter in migraine patients
MRI radiomics based machine learning model of the periaqueductal gray matter in migraine patients
Background and purpose – The aim of the study was to investigate the question: Can MRI radiomics analysis of the periaqueductal gray region elucidate the pathophysiological mechani...
Primerjalna književnost na prelomu tisočletja
Primerjalna književnost na prelomu tisočletja
In a comprehensive and at times critical manner, this volume seeks to shed light on the development of events in Western (i.e., European and North American) comparative literature ...
Hippocampal β-adrenergic system modulates recognition memory reconsolidation
Hippocampal β-adrenergic system modulates recognition memory reconsolidation
Abstract
Targeting reconsolidation with propranolol, a blocker of β-adrenergic receptors (β-ARs), emerged as a potential treatment for maladaptive memories such as ...
Atrial fibrillation and migraine with aura in young adults with ischemic stroke
Atrial fibrillation and migraine with aura in young adults with ischemic stroke
Background Migraine is associated with an increased risk of ischemic stroke. The associations are stronger in migraine with aura than in migraine without aura, in women than in men...
Vestibular Migraine in Adolescents
Vestibular Migraine in Adolescents
Migraine is a recurrent throbbing headache that affects one side of the head and is usually related to nausea and decreased vision. Migraine is typically seen in adolescents due to...
Inheritance of Cluster Headache and its Possible Link to Migraine
Inheritance of Cluster Headache and its Possible Link to Migraine
SYNOPSIS
We evaluated the possibility that cluster headache may be a transmitted disorder, influenced by migraine genetics. In the first part of a two part study,...
Migraine Headache: A Bangladesh Perspective
Migraine Headache: A Bangladesh Perspective
Background: Migraine headache is one of the commonest cause of primary headache. This study aims to reveal the clinical profile of migraine headache in Bangladeshi people presented...