Changes in glucose metabolism during detachment of metastatic cells

The purpose of the work is to investigate changes in survival rates, proliferative potential, glucose metabolism and redox metabolism in metastatically active cells of Lewis lung carcinoma during the transition from anchorage-dependent to anchorage-independent growth. It was shown that the transition from anchorage-dependent growth to anchorage-independent growth is accompanied by a considerable intensification of glucose consumption rate. An increase in glucose consumption during anchorage-independent growth does not cause stimulation of proliferative activity. An increase in glucose consumption and a decrease in proliferative activity indicates a redirection of glucose to the synthesis of enzymes of the antioxidant system in order to prevent apoptotic death during anchorage-independent growth.