A Review on Emerging Insights and Novel Innovations in Quinoline Derivatives

Abstract: Quinoline derivatives are considered highly promising for developing anticancer drugs due to their ability to disrupt essential cellular processes by inserting themselves between DNA base pairs. This interference inhibits crucial activities like DNA replication and transcription, making these compounds effective against cancer cells, thereby further boosting their potential to improve overall treatment outcomes. The synthesis of quinoline derivatives involves several named reactions such as the Riehm Quinoline Synthesis, Doebner reaction, Doebner Miller reaction, Gould-Jacobs reaction, Conrad-Limpach synthesis, Combes quinoline synthesis, Skraup reaction, and many others. Furthermore, the novel innovations by various researchers described in this article allow for the production of novel derivatives with specific substitution patterns and biological activities, enabling researchers to optimize pharmacological properties like bioavailability and target specificity. Recent studies have yielded quinoline derivatives that exhibit an increased ability to kill cancer cells and greater specificity for different types of cancer. Moreover, many researchers have demonstrated the strong effectiveness of quinoline derivatives against tumors in early-stage testing, setting the stage for continued research and clinical trials. Thus, quinoline derivatives show great potential in combating cancer, presenting new opportunities for developing innovative therapies for cancer treatment.