Clinicohematological profile of patients with Pancytopenia

Background: Pancytopenia is common and important clinico-hematological problem encountered in our daily clinicalpractice. The pattern of diseases leading to Pancytopenia is expected to varying in different population groups withdifference in age pattern, nutritional status, and prevalence of infective disorders. The severity of pancytopenia and theunderlying pathology determine the management and prognosisObjectives: To study the etiology and clinic-hematological profile in patients of peripheral blood pancytopeniaMaterials and Methods: This was a prospective study conducted at Uttar Pradesh University of medical sciences, Saifai,Etawah during the period of January 2019 to June 2021.Results: A total of 202 patients (108 males and 94 females) were diagnosed to have pancytopenia. Most of the patientspresented with generalized weakness and fever. The commonest physical finding was pallor, followed by spleenomegaly.The various causes of pancytopenia included infections(n=138), megaloblastic anaemia (MA)(n=44), drugs, aplasticanaemia and subleukaemic leukaemia. We found a significant association between megaloblastic anaemia andpancytopeniaConclusion: The present study concluded that infection and megaloblastic anaemia are the most common cause ofpancytopenia.