Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
The Reduction of JunB Inhibits the Odontogenic Differentiation Potential of the DPSCs by Targeting PIN1 in Pulpitis
View through CrossRef
Abstract
Pulpitis is an inflammatory condition that can lead to the loss of tooth vitality. The odontogenic differentiation potential of the dental pulp stem cells (DPSCs) is significantly decreased in the pulpitis microenvironment. The aim of this study was to determine the mechanism of the impaired odontogenic differentiation of the DPSCs in an inflammatory microenvironment. Overexpression and inhibition of the JunB were performed to evaluate its effect on the odontogenic differentiation potential of the DPSCs. The results showed that the JunB was positively correlated with the odontogenic differentiation ability of the DPSCs. The co-immunoprecipitation assay coupled with the mass spectrometry showed that peptidyl-prolyl cis-trans Isomerase NIMA-Interacting 1 (PIN1) was a downstream target of the JunB. Moreover, the expression of PIN1 was negatively correlated with the odontogenic differentiation potential of the DPSCs. Taken together, the decreased expression level of the JunB in an inflammatory state can impair the odontogenic differentiation ability of the DPSCs by upregulating the expression of the PIN1, a negative regulator of the odontogenic differentiation of the DPSCs.
Springer Science and Business Media LLC
Title: The Reduction of JunB Inhibits the Odontogenic Differentiation Potential of the DPSCs by Targeting PIN1 in Pulpitis
Description:
Abstract
Pulpitis is an inflammatory condition that can lead to the loss of tooth vitality.
The odontogenic differentiation potential of the dental pulp stem cells (DPSCs) is significantly decreased in the pulpitis microenvironment.
The aim of this study was to determine the mechanism of the impaired odontogenic differentiation of the DPSCs in an inflammatory microenvironment.
Overexpression and inhibition of the JunB were performed to evaluate its effect on the odontogenic differentiation potential of the DPSCs.
The results showed that the JunB was positively correlated with the odontogenic differentiation ability of the DPSCs.
The co-immunoprecipitation assay coupled with the mass spectrometry showed that peptidyl-prolyl cis-trans Isomerase NIMA-Interacting 1 (PIN1) was a downstream target of the JunB.
Moreover, the expression of PIN1 was negatively correlated with the odontogenic differentiation potential of the DPSCs.
Taken together, the decreased expression level of the JunB in an inflammatory state can impair the odontogenic differentiation ability of the DPSCs by upregulating the expression of the PIN1, a negative regulator of the odontogenic differentiation of the DPSCs.
Related Results
Data from Jun Proteins Are Starvation-Regulated Inhibitors of Autophagy
Data from Jun Proteins Are Starvation-Regulated Inhibitors of Autophagy
<div>Abstract<p>The growing number of biological functions affected by autophagy ascribes a special significance to identification of factors regulating it. The activat...
Data from Jun Proteins Are Starvation-Regulated Inhibitors of Autophagy
Data from Jun Proteins Are Starvation-Regulated Inhibitors of Autophagy
<div>Abstract<p>The growing number of biological functions affected by autophagy ascribes a special significance to identification of factors regulating it. The activat...
Data from The Peptidyl-Prolyl Isomerase Pin1 Regulates Cytokinesis through Cep55
Data from The Peptidyl-Prolyl Isomerase Pin1 Regulates Cytokinesis through Cep55
<div>Abstract<p>Failure of cytokinesis results in tetraploidy and can increase the genomic instability frequently observed in cancer. The peptidyl-prolyl isomerase Pin1...
Data from The Peptidyl-Prolyl Isomerase Pin1 Regulates Cytokinesis through Cep55
Data from The Peptidyl-Prolyl Isomerase Pin1 Regulates Cytokinesis through Cep55
<div>Abstract<p>Failure of cytokinesis results in tetraploidy and can increase the genomic instability frequently observed in cancer. The peptidyl-prolyl isomerase Pin1...
Evaluation of dental pulp stem cells response to flowable nano-hybrid dental composites: A comparative analysis
Evaluation of dental pulp stem cells response to flowable nano-hybrid dental composites: A comparative analysis
Background
Flowable resin composites (FRC) are tooth-colored restorative materials that contain a lower filler particle content, and lower viscosity than their bulk counterparts, m...
PIN1-Independent Leaf Initiation in Arabidopsis
PIN1-Independent Leaf Initiation in Arabidopsis
AbstractPhyllotaxis, the regular arrangement of leaves and flowers around the stem, is a key feature of plant architecture. Current models propose that the spatiotemporal regulatio...
GSK3β Rephosphorylation Rescues ALPL Deficiency Induced-impairment of Odontoblastic Differentiation of DPSCs
GSK3β Rephosphorylation Rescues ALPL Deficiency Induced-impairment of Odontoblastic Differentiation of DPSCs
Abstract
Background: Premature exfoliation of deciduous teeth is a common manifestation in childhood patients with Hypophosphatasia (HPP), which is an autosomal inherited d...
Dentin Particulate for Bone Regeneration: An In Vitro Study
Dentin Particulate for Bone Regeneration: An In Vitro Study
The aim of this in vitro study was to investigate the commitment and behavior of dental pulp stem cells (DPSCs) seeded onto two different grafting materials, human dentin particula...