Antimicrobial and antioxidative properties of Cleome viscose leaf extract

Abstract The annual, sticky plant Cleome viscose Linn. (Capparidaceae), sometimes known as "Jakhya," thrives as a weed across India's plains and throughout the tropics. The entire plant and its components are extensively used in traditional and folklore medicine (seeds, leaves, roots and barks). We evaluated the antimicrobial and antioxidant capacity of Cleome viscose leaf extract.Methods: Methanol was used to extract the leaves. Extract was analysed qualitatively and quantitatively. Antioxidative properties of extract was assayed using DPPH, FRAP, ABTS H2O2 scavenging assay. Correlation between antioxidant activity, phenolic content and flavonoid content was estimated. Antimicrobial activity of Cleome viscose Linn leaf methanolic extract was estimated against Staphylococcus aureus, Vibrio cholera, Salmonella Typhimurium.Result: The methanolic extract of Cleome viscose leaves showed good antioxidant and antimicrobial potential. The extract was having alkaloids, phenolics, flavonoids and tannins as major phytochemicals. The extract showed good ABTS scavenging activity and moderate DPPH scavenging activity. The TPC strongly while TFC moderately correlated with antioxidant activity of the extract.Conclusion: Methanolic extract of Cleome viscose leaves demonstrated significant antioxidant and antibacterial activity. The phytoconstituents found in plant leaves, primarily phenolics, flavonoids, alkaloids, and tannins, are thought to be responsible for the plant's antioxidant and antimicrobial properties, making it a therapeutically important plant with the potential to be used as a drug as an antioxidant or against microbial diseases.