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Development of a PROTAC Targeting Chk1
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A series of Chk1 degraders were designed and synthesized. The degraders were developed through the conjugation of a promiscuous kinase binder and thalidomide. One of the degraders PROTAC-2 was able to decrease Chk1 levels in a concentration-dependent manner in A375 cells. The developed probes can be useful for the development of selective and more potent Chk1 degraders.
Cold Spring Harbor Laboratory
Title: Development of a PROTAC Targeting Chk1
Description:
A series of Chk1 degraders were designed and synthesized.
The degraders were developed through the conjugation of a promiscuous kinase binder and thalidomide.
One of the degraders PROTAC-2 was able to decrease Chk1 levels in a concentration-dependent manner in A375 cells.
The developed probes can be useful for the development of selective and more potent Chk1 degraders.
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