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DNA-Binding and Photocleavage Behaviour of [Ru(bpy)2(MDPZ)]2+
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The new ligand MDPZ (MDPZ = 7,7'-methylenedioxyphenyldipyrido[3,2-a:2',3'-c]-phenazine and its RuII complex [Ru(bpy)2(MDPZ)]2+ (phen = 1,10-phenanthroline) was synthesized and characterized by elemental analysis, mass spectrometry, and 1H NMR spectroscopy. The DNA-binding properties of [Ru(bpy)2(MDPZ)]2+ were investigated by different spectrophotometric methods and viscosity measurements. The results suggest that the complex binds to CT-DNA through intercalation, and can enantioselectively interact with CT-DNA. Although the [Ru(bpy)2(MDPZ)]2+ complex does not show the characteristics of a molecular ‘light switch’ for DNA, [Ru(phen)2(MDPZ)]2+ may serve as a sensitive luminescent probe for DNA. Also, when irradiated at 365 nm, the complex promotes the photocleavage of pBR 322 DNA.
Title: DNA-Binding and Photocleavage Behaviour of [Ru(bpy)2(MDPZ)]2+
Description:
The new ligand MDPZ (MDPZ = 7,7'-methylenedioxyphenyldipyrido[3,2-a:2',3'-c]-phenazine and its RuII complex [Ru(bpy)2(MDPZ)]2+ (phen = 1,10-phenanthroline) was synthesized and characterized by elemental analysis, mass spectrometry, and 1H NMR spectroscopy.
The DNA-binding properties of [Ru(bpy)2(MDPZ)]2+ were investigated by different spectrophotometric methods and viscosity measurements.
The results suggest that the complex binds to CT-DNA through intercalation, and can enantioselectively interact with CT-DNA.
Although the [Ru(bpy)2(MDPZ)]2+ complex does not show the characteristics of a molecular ‘light switch’ for DNA, [Ru(phen)2(MDPZ)]2+ may serve as a sensitive luminescent probe for DNA.
Also, when irradiated at 365 nm, the complex promotes the photocleavage of pBR 322 DNA.
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