Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
FUMA: Functional mapping and annotation of genetic associations
View through CrossRef
ABSTRACT
A main challenge in genome-wide association studies (GWAS) is to prioritize genetic variants and identify potential causal mechanisms of human diseases. Although multiple bioinformatics resources are available for functional annotation and prioritization, a standard, integrative approach is lacking. We developed FUMA: a web-based platform to facilitate functional annotation of GWAS results, prioritization of genes and interactive visualization of annotated results by incorporating information from multiple state-of-the-art biological databases.
Title: FUMA: Functional mapping and annotation of genetic associations
Description:
ABSTRACT
A main challenge in genome-wide association studies (GWAS) is to prioritize genetic variants and identify potential causal mechanisms of human diseases.
Although multiple bioinformatics resources are available for functional annotation and prioritization, a standard, integrative approach is lacking.
We developed FUMA: a web-based platform to facilitate functional annotation of GWAS results, prioritization of genes and interactive visualization of annotated results by incorporating information from multiple state-of-the-art biological databases.
Related Results
Principes et outils pour l’annotation des corpus
Principes et outils pour l’annotation des corpus
La linguistique de corpus, c’est à dire les recherches sur le langage portant sur un matériel linguistique écrit ou oral recueilli et conservé, s’est considérablement développée au...
Are Cervical Ribs Indicators of Childhood Cancer? A Narrative Review
Are Cervical Ribs Indicators of Childhood Cancer? A Narrative Review
Abstract
A cervical rib (CR), also known as a supernumerary or extra rib, is an additional rib that forms above the first rib, resulting from the overgrowth of the transverse proce...
Aligning functional network constraint to evolutionary outcomes
Aligning functional network constraint to evolutionary outcomes
Summary
It is likely that there are constraints on how evolution can progress, and well-known evolutionary phenomena such as convergent evolution, rapid adaptation,...
Benchmarking Hayai-Annotation Plants: A Re-evaluation Using Standard Evaluation Metrics
Benchmarking Hayai-Annotation Plants: A Re-evaluation Using Standard Evaluation Metrics
Abstract
The rapid growth of next-generation sequencing (NGS) technology has led to a surge in the determination of whole genome sequences in pla...
Mapping workflow trends in pulsed-field ablation procedures: an international glimpse
Mapping workflow trends in pulsed-field ablation procedures: an international glimpse
Abstract
Background
As pulsed field ablation (PFA) is increasingly used in the EP lab, the use of mapping, fluoroscopy, and intr...
Functional annotation with expression validation identifies novel metastasis-relevant genes from post-GWAS risk loci in sporadic colorectal carcinomas
Functional annotation with expression validation identifies novel metastasis-relevant genes from post-GWAS risk loci in sporadic colorectal carcinomas
AbstractColorectal cancer (CRC) is the third highest incidence cancer and leading cause of cancer mortality worldwide. Metastasis to distal organ is the major cause of cancer morta...
An extensible genome annotation workbench based on the Galaxy Platform
An extensible genome annotation workbench based on the Galaxy Platform
Introduction
Falling costs of genetic sequencing have allowed sequencing and annotation of the genomes of non-model organism. In annotating non-mod...
FAMUS: A Few-Shot Learning Framework for Large-Scale Protein Annotation
FAMUS: A Few-Shot Learning Framework for Large-Scale Protein Annotation
Predicting gene function is a pivotal and challenging step in genomic and metagenomic data analysis. Current automatic annotation tools typically rely on the single most similar se...