Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Nuclear soluble cGAS senses DNA virus infection
View through CrossRef
ABSTRACT
The cytosolic DNA sensor cGAS detects foreign DNA from pathogens or self-DNA from cellular damage and instigates type I interferon (IFN) expression. Recent studies find that cGAS also localizes in the nucleus and binds the chromatin. Despite how cGAS is inhibited in the nucleus is well elucidated, whether nuclear cGAS participates in DNA sensing is not clear. Here, we report that herpes simplex virus 1 (HSV-1) infection caused the release of cGAS from the chromatin into the nuclear soluble fraction. Like its cytosolic counterpart, the leaked nuclear soluble cGAS could sense viral DNA, produce cGAMP, and induce mRNA expression of type I IFN and interferon-stimulated genes. Furthermore, the nuclear cGAS limited HSV-1 infection. Taken together, our study demonstrates that HSV-1 infection releases cGAS from the chromatin tethering and, in turn, the nuclear soluble cGAS activates type I IFN production.
Title: Nuclear soluble cGAS senses DNA virus infection
Description:
ABSTRACT
The cytosolic DNA sensor cGAS detects foreign DNA from pathogens or self-DNA from cellular damage and instigates type I interferon (IFN) expression.
Recent studies find that cGAS also localizes in the nucleus and binds the chromatin.
Despite how cGAS is inhibited in the nucleus is well elucidated, whether nuclear cGAS participates in DNA sensing is not clear.
Here, we report that herpes simplex virus 1 (HSV-1) infection caused the release of cGAS from the chromatin into the nuclear soluble fraction.
Like its cytosolic counterpart, the leaked nuclear soluble cGAS could sense viral DNA, produce cGAMP, and induce mRNA expression of type I IFN and interferon-stimulated genes.
Furthermore, the nuclear cGAS limited HSV-1 infection.
Taken together, our study demonstrates that HSV-1 infection releases cGAS from the chromatin tethering and, in turn, the nuclear soluble cGAS activates type I IFN production.
Related Results
The cytoplasmic DNA sensor cGAS promotes mitotic cell death
The cytoplasmic DNA sensor cGAS promotes mitotic cell death
AbstractThe cyclic GMP-AMP (cGAMP) synthase cGAS counteracts infections by detecting and binding foreign cytoplasmic DNA1. DNA-induced synthesis of cGAMP activates innate immune si...
Abstract B004: cGAS promote DLBCL survival through STAT3 and NF-κB signaling
Abstract B004: cGAS promote DLBCL survival through STAT3 and NF-κB signaling
Abstract
The innate immunity cGAS–STING signaling has been extensively studied to boost lymphocytes infiltration for tumor inhibition/eradication. However, DLBCL cel...
cGAS is predominantly a nuclear protein
cGAS is predominantly a nuclear protein
cGAS is an intracellular innate immune sensor that detects double-stranded DNA. The presence of billions of base pairs of genomic DNA in all nucleated cells raises the question of ...
Regulation of cGAS activity through RNA-mediated phase separation
Regulation of cGAS activity through RNA-mediated phase separation
Abstract
Cyclic GMP-AMP synthase (cGAS) is a double-stranded DNA (dsDNA) sensor that functions in the innate immune system. Upon binding dsDNA in...
A non-canonical cGAS-STING pathway drives cellular and organismal aging
A non-canonical cGAS-STING pathway drives cellular and organismal aging
Abstract
Accumulation of cytosolic DNA has emerged as a hallmark of aging, inducing sterile inflammation. STING (Stimulator of Interferon Genes) protein translates ...
Targeting the cGAS‐STING Pathway Inhibits Peripheral T‐cell Lymphoma Progression and Enhances the Chemotherapeutic Efficacy
Targeting the cGAS‐STING Pathway Inhibits Peripheral T‐cell Lymphoma Progression and Enhances the Chemotherapeutic Efficacy
AbstractPeripheral T‐cell lymphoma (PTCL) is a highly heterogeneous group of mature T‐cell malignancies. The efficacy of current first‐line treatment is dismal, and novel agents ar...
Vaccinia virus E5 is a dominant inhibitor of the cytosolic DNA sensor cGAS
Vaccinia virus E5 is a dominant inhibitor of the cytosolic DNA sensor cGAS
Abstract
The cytosolic DNA sensor cGAS plays an important role in detecting viral nucleic acid, which leads to type I IFN production. We have previously shown that i...