LIVER CIRRHOSIS ON HISTOMORPHOLOGY AND VITAMIN D DEFICIENCY: A CROSS-SECTIONAL STUDY AT TERTIARY CARE HOSPITAL OF PESHAWAR, PAKISTAN

Objectives: To estimate the frequency of vitamin D insuffi ciency in individuals with cirrhosis of the liver based on histomorphology.Methods and materials: In the current investigation, 148 patients were tracked to determine the incidence of vitamin D insuffi ciency in adults with liver cirrhosis based on histomorphology. All those participants, both males and females, with liver cirrhosis (of any severity) for at least 06 months and aged 30 to 60 years were included whereas, the individuals with osteomalacia or vitamin D insufficiency (as determined by medical records) and chronic renal failure (as determined by specifi c investigations or medical records) were excluded in the study.All patients presenting to OPD meeting the inclusion criteria i.e. people with cirrhosis. Vitamin D insuffi ciency was stratified by age, gender, and disease duration to examine the impact modifi ers using the chi square test having a p-value of <0.05 regarded as noteworthy by Using SPSS version 20.Results: In the present study, the age distribution of 148 patients was examined which was; from 30-40 years were 41 (27.7%), 41-50 years were 60 (40.5%) and from 51-60 years were 47(31.8%). Average age was 55.56±3.357 years. Gender wise distribution among 148 patients was analysed as; males were 94 (63.5%) and females were 54 (36.5%). Distribution of BMI classifi cation among 148 patients was analysed as; below 18.5 (underweight) was 60 (40.5%), 18.5-24.9 (normal weight) were 43 (29.1%), 25.0-29.9 (pre-obesity) were 19 (12.8%) and 30.0-34.9 (obesity class) were 26 (17.6%). Distribution of diabetes among 148 patients were analysed as; Yes was found in 57 (38.5%) and No was found in 91 (61.5%). Distribution of smoking among 148 patients were analyzed as; Yes, was found in 51 (34.5%) whereas No was found in 97(65.5%).Conclusion: The link between vitamin D and liver cirrhosis on histomorphology has significant therapeutic promise. We expect to look into a variety of extra-skeletal indications in the near future. The link between vitamin D defi cit and liver function, infectious effects, and fi brosis may back its use as a prognostic as well as suggestive tool.