CLINICO-HEMATOLOGICAL PROFILE IN FEBRILE THROMBOCYTOPENIA

Background: Febrile thrombocytopenia is one of the common clinical entities in practice. Various infections can cause a low platelet count. Dengue fever is the common cause followed by sepsis, malaria and others. Along with platelet count, other haematological parameters do show some signicant changes which help in the diagnosis and prognosis of the disease. Hematocrit and platelet indices especially mean platelet volume and platelet distribution width help in the assessment of the severity in dengue infections. Aims and Objectives: 1) To study various causes of febrile thrombocytopenia . 2) To analyze the clinical prole and hematological parameters in patients with febrile thrombocytopenia. 3) To analyse hematological parameters in Primary and Secondary dengue patients. Materials and Methods: A total of 122 febrile thrombocytopenia patients were included in the study. Relevant history and clinical examination data was collected. Complete blood count and peripheral smear were evaluated. Serology test reports were collected from the microbiology department. The hematological parameters, with special reference to platelet indices, were assessed in various causes of Primary and Secondary dengue and non-dengue cases of febrile thrombocytopenic patients. Febrile thrombocytopenia was comm Results: only seen in the 2nd decade, with male preponderance. Dengue was the common cause of febrile thrombocytopenia. Thirty-one cases of dengue had bleeding manifestations. There were 11 primary and 60 secondary dengue cases. High hematocrit, atypical lymphocytosis, platelet indices were more signicant in secondary dengue. Platelet indices were also signicant in dengue with bleeding manifestations. Diagnosis of dengue and early Conclusion: management are necessary to avoid complications. Hematological parameters show signicant changes in dengue patients and especially in secondary dengue. The simple, cost-effective tests help in the assessment of the disease severity.