Recovery From Amiodarone-Induced Cornea Verticillata by Application of Topical Heparin

Purpose: To report a case of amiodarone-induced vortex keratopathy–associated anatomical findings and subjective visual perception before and after treatment with topical heparin eye drops. Methods: Case report. Results: A 76-year-old man complained of halos in his vision in both his eyes due to prominent bilateral cornea verticillata. For treatment of cornea verticillata, we prescribed unpreserved eye drops of a sterile, phosphate-free solution of 0.1% sodium hyaluronate with 1300 IU/mL heparin sodium 3 times daily to the left eye, whereas the other side served as the control. The area of corneal deposits was measured by 2 examiners before and at the 1- and 3-month examination. At last follow-up, cornea verticillata had been reduced from 6 to 2 mm2 in area by approximately 66% from grade-III to grade-II amiodarone keratopathy. Conclusions: In patients using amiodarone, clearing of cornea verticillata may be achieved by topical use of unpreserved eye drops of a sterile, phosphate-free solution of 0.1% sodium hyaluronate with 1300 IU/mL heparin sodium.