Involvement of Osteonectin and Matrix metaloproteinas-8 in pathogenesis of Periimplantitis

Periimplantitis is a condition that can be described by inflammation of the soft tissues and bone loss around the implant. It is a disorder that causes inflammation and increases the synthesis and activation of cytokines. The aim of the present study was to investigate salivary osteonectin and matrix metaloproteinas 8 (MMP8) levels in periimplant health and periimplantitis, to determin the correlation between osteonectin and MMP8 in periimplantitis patients. Methods Forty-five patients with peri-implantitis, and 44 individuals with peri-implant health as a control group have participated in the research. Modified sulcus bleeding index(MSBI), modified plaque index (MPI), and probing depth (PD)were among the actual indicators that were noted. The saliva samples collected then osteonectin and MMP8 levels were analyzed by ELISA. Results, there were significant differences in salivary osteonectin and MMP8 levels of periimplantitis compared to periimplant healthy controls groups. Periodontal clinical parameters were significantly correlated with salivary osteonectin and MMP8 levels in periimplantitis groups. There was significant correlation of osteonectin with MMP8. Conclusions periimplantitis patients were showed that increased saliva levels of osteonectin and MMP8. The elevated level of osteonectin supports their participation in bone resorption via altering control of bone remodeling, as shown in periimplantitis. MMP8 has the potential function in periodontal tissue deterioration and can be used to assess the progressing of periimplant disorders. Therefor these significant findings of the two biomarkers may have a potential role in pathogenesis of periimplantitis.