Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Renal Ischemia/Reperfusion Injury in Diabetic Rats: The Role of Local Ischemic Preconditioning
View through CrossRef
Background. The aim of this study was to evaluate the effects of local ischemic preconditioning using biochemical markers and histopathologically in the diabetic rat renal IR injury model.Methods. DM was induced using streptozotocin. Rats were divided into four groups: Group I, nondiabetic sham group (n=7), Group II, diabetic sham group (n=6), Group III, diabetic IR group (diabetic IR group,n=6), and Group IV, diabetic IR + local ischemic preconditioning group (diabetic IR + LIPC group,n=6). Ischemic renal injury was induced by clamping the bilateral renal artery for 45 min. 4 h following ischemia, clearance protocols were applied to assess biochemical markers and histopathologically in rat kidneys.Results. The histomorphologic total cell injury scores of the nondiabetic sham group were significantly lower than diabetic sham, diabetic IR, and diabetic IR + LIPC groups. Diabetic IR group scores were not significantly different than the diabetic sham group. But diabetic IR + LIPC group scores were significantly higher than the diabetic sham and diabetic IR groups.Conclusion. Local ischemic preconditioning does not reduce the risk of renal injury induced by ischemia/reperfusion in diabetic rat model.
Title: Renal Ischemia/Reperfusion Injury in Diabetic Rats: The Role of Local Ischemic Preconditioning
Description:
Background.
The aim of this study was to evaluate the effects of local ischemic preconditioning using biochemical markers and histopathologically in the diabetic rat renal IR injury model.
Methods.
DM was induced using streptozotocin.
Rats were divided into four groups: Group I, nondiabetic sham group (n=7), Group II, diabetic sham group (n=6), Group III, diabetic IR group (diabetic IR group,n=6), and Group IV, diabetic IR + local ischemic preconditioning group (diabetic IR + LIPC group,n=6).
Ischemic renal injury was induced by clamping the bilateral renal artery for 45 min.
4 h following ischemia, clearance protocols were applied to assess biochemical markers and histopathologically in rat kidneys.
Results.
The histomorphologic total cell injury scores of the nondiabetic sham group were significantly lower than diabetic sham, diabetic IR, and diabetic IR + LIPC groups.
Diabetic IR group scores were not significantly different than the diabetic sham group.
But diabetic IR + LIPC group scores were significantly higher than the diabetic sham and diabetic IR groups.
Conclusion.
Local ischemic preconditioning does not reduce the risk of renal injury induced by ischemia/reperfusion in diabetic rat model.
Related Results
Possible involvement of Poly (ADP-ribose) polymerase (PARP) in the cardioprotective potential of ischemic postconditioning in rat heart
Possible involvement of Poly (ADP-ribose) polymerase (PARP) in the cardioprotective potential of ischemic postconditioning in rat heart
Objective
The present study has been designed to investigate the possible role of Poly (ADP-ribose) polymerase (PARP) and protein kinase C-delta (PKC-δ) in myocar...
Additive Effects of Late Preconditioning Produced By Monophosphoryl Lipid A and the Early Preconditioning Mediated By Adenosine Receptors and K
ATP
Channel
Additive Effects of Late Preconditioning Produced By Monophosphoryl Lipid A and the Early Preconditioning Mediated By Adenosine Receptors and K
ATP
Channel
Background
—The cardioprotective effect of preconditioning can be exerted within 1 to 2 hours after initial ischemia, termed classical or early preconditioning, or can ...
Renal ischemia-reperfusion injury attenuated by exosomes extracted from splenic ischemic preconditioning
Renal ischemia-reperfusion injury attenuated by exosomes extracted from splenic ischemic preconditioning
Abstract
Objective
To investigate the protective effects of the exosomes extracted from splenic ischemic preconditioning (sIPC)...
The Assessment of Reperfusion Inflammatory Injury in Ischemic Preconditioned Diabetic Rats
The Assessment of Reperfusion Inflammatory Injury in Ischemic Preconditioned Diabetic Rats
Abstract
Objective: The assessment of systemic reperfusion injury and the contractile force of the peripheral muscles post-acute ischemia of the h...
Autoantibodies against β3-adrenoceptor reduce the susceptibility to myocardial ischemic/reperfusion injury of heart failure rats
Autoantibodies against β3-adrenoceptor reduce the susceptibility to myocardial ischemic/reperfusion injury of heart failure rats
Objective
Choosing chronic heart failure rats as starting point, to observe whether Autoantibodies against β3-adrenoceptor (β3AA) can reduce the susceptibility to...
Preconditioning with rHMGB1 ameliorates lung ischemia–reperfusion injury through inhibiting alveolar macrophages pyroptosis via Keap1/Nrf2/HO-1 signal pathway
Preconditioning with rHMGB1 ameliorates lung ischemia–reperfusion injury through inhibiting alveolar macrophages pyroptosis via Keap1/Nrf2/HO-1 signal pathway
Abstract
Background: Lung ischemia-reperfusion injury (LIRI) is a common and complex pathophysiological process that can lead to poor patient outcomes. Inflammasome-depende...
Preconditioning prevents chronic reperfusion-induced coronary endothelial dysfunction in rats
Preconditioning prevents chronic reperfusion-induced coronary endothelial dysfunction in rats
Experiments were designed to test whether preconditioning protects against chronic endothelial injury after ischemia and reperfusion. Coronary arteries were isolated from rats subj...
Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode.
Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode.
We have shown previously that preconditioning myocardium with four 5-minute episodes of ischemia and reperfusion dramatically limited the size of infarcts caused by a subsequent 40...