Abstract 160: Frequency of Ideal Cardiovascular Health Metrics in the SAMMPRIS Trial

Purpose: The number of ideal cardiovascular health metrics as defined by the American Heart Association (AHA) Life’s Simple 7 has previously been associated with a significantly lower risk of cardiovascular disease and stroke in community studies. The objective of our study was to determine the frequency of ideal cardiovascular health metrics at baseline among participants enrolled in the SAMMPRIS trial and to compare metrics by race and sex. Methods: SAMMPRIS randomized 451 patients with symptomatic 70%-99% intracranial stenosis to aggressive medical management or stenting plus aggressive medical management at 50 US sites. We evaluated seven modifiable cardiovascular disease risk factors at baseline and categorized them as ideal based on criteria modified from the AHA definition of Life’s Simple 7. Baseline metrics were compared by race and sex using Fisher’s exact test. Results: The frequency of ideal health metrics is shown in Table 1. Of participants with data available on all metrics, the majority (57%) had 0-1 ideal AHA metrics. Non-whites were less likely than whites to have ideal nonsmoking behavior (56% vs 68%, p=0.017) and ideal fasting glucose (21% vs 36%, p=0.046). Women were less likely than men to have ideal physical activity status (15% vs 27%, p=0.002) but more likely to have ideal nonsmoking behavior (70% vs 61%, p=0.035). Conclusions: At baseline, participants enrolled in the SAMMPRIS trial had a low frequency of ideal cardiovascular health metrics. Future analyses will relate the frequency of these metrics to outcomes in the trial.