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Exosomal-microRNAs Improve Islet Cell Survival and Function In Islet Transplantation
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Abstract:
Exosomal-microRNAs (Exo-miRNAs) are key regulators of islet cell function, including insulin
expression, processing, and secretion. Exo-miRNAs have a significant impact on the outcomes of islet
transplantation as biomarkers for evaluating islet cell function and survival. Furthermore, they have been
linked to vascular remodeling and immune regulation following islet transplantation. Mesenchymal stem
cell-derived exosomes have been shown in preliminary studies to improve islet cell viability and function
when injected or transplanted into mice. Overall, Exo-miRNAs have emerged as novel agents for improving
islet transplantation success rates. The role of islet-derived Exo-miRNAs and mesenchymal stem
cells-derived Exo-miRNAs as biomarkers and immunomodulators in islet regeneration, as well as their
role in improving islet cell viability and function in islet transplantation, are discussed in this review.
Bentham Science Publishers Ltd.
Title: Exosomal-microRNAs Improve Islet Cell Survival and Function In Islet
Transplantation
Description:
Abstract:
Exosomal-microRNAs (Exo-miRNAs) are key regulators of islet cell function, including insulin
expression, processing, and secretion.
Exo-miRNAs have a significant impact on the outcomes of islet
transplantation as biomarkers for evaluating islet cell function and survival.
Furthermore, they have been
linked to vascular remodeling and immune regulation following islet transplantation.
Mesenchymal stem
cell-derived exosomes have been shown in preliminary studies to improve islet cell viability and function
when injected or transplanted into mice.
Overall, Exo-miRNAs have emerged as novel agents for improving
islet transplantation success rates.
The role of islet-derived Exo-miRNAs and mesenchymal stem
cells-derived Exo-miRNAs as biomarkers and immunomodulators in islet regeneration, as well as their
role in improving islet cell viability and function in islet transplantation, are discussed in this review.
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