Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Ischemic preconditioning fails to confer additional protection against ischemia-reperfusion injury in the hypothyroid rat heart
View through Europeana Collections
There is accumulating evidence showing that ischemic preconditioning (PC) may lose its cardioprotective effect in the diseased states. The present study investigated whether PC can be effective in hypothyroidism, a clinical condition which is common and often accompanies cardiac diseases such as heart failure and myocardial infarction. Hypothyroidism was induced in rats by 3-week administration of 6n-propyl-2-thiouracil in water (0.05 %). Normal and hypothyroid hearts (HYPO) were perfused in Langendorff mode and subjected to 20 min of zero-flow global ischemia and 45 min of reperfus ion. A preconditioning protocol (PC) was also applied prior to ischemia. HYPO hearts had significantly improved post-ischemic recovery of left ventricular developed pressure, end-diastolic pressure and reduced lactate dehydrogenase release. Furthermore, phospho-JNK and p38 MAPK levels after ischemia and reperfusion were 4.0 and 3.0 fold lower in HYPO as compared to normal hearts ( P
Title: Ischemic preconditioning fails to confer additional protection against ischemia-reperfusion injury in the hypothyroid rat heart
Description:
There is accumulating evidence showing that ischemic preconditioning (PC) may lose its cardioprotective effect in the diseased states.
The present study investigated whether PC can be effective in hypothyroidism, a clinical condition which is common and often accompanies cardiac diseases such as heart failure and myocardial infarction.
Hypothyroidism was induced in rats by 3-week administration of 6n-propyl-2-thiouracil in water (0.
05 %).
Normal and hypothyroid hearts (HYPO) were perfused in Langendorff mode and subjected to 20 min of zero-flow global ischemia and 45 min of reperfus ion.
A preconditioning protocol (PC) was also applied prior to ischemia.
HYPO hearts had significantly improved post-ischemic recovery of left ventricular developed pressure, end-diastolic pressure and reduced lactate dehydrogenase release.
Furthermore, phospho-JNK and p38 MAPK levels after ischemia and reperfusion were 4.
0 and 3.
0 fold lower in HYPO as compared to normal hearts ( P.
Related Results
Severity of lethal ischemia/reperfusion injury in rat hearts subjected to ischemic preconditioning is increased under conditions of simulated hyperglycemia
Severity of lethal ischemia/reperfusion injury in rat hearts subjected to ischemic preconditioning is increased under conditions of simulated hyperglycemia
The aim of our study was to characterize resistance to ischemia/reperfusion (I/R) injury in Langendorff-perfused rat hearts and effectivity of ischemic preconditioning (PC) under c...
Effect of maturation on the resistance of rat hearts against ischemia. Study of potential molecular mechanisms
Effect of maturation on the resistance of rat hearts against ischemia. Study of potential molecular mechanisms
a1_Reduced tolerance to ischemia/reperfusion (IR) injury has been shown in elder human and animal hearts, however, the onset of this unfavorable phenotype and cellular mechanisms b...
Reduced susceptibility to ischemia-induced arrhythmias in the preconditioned rat heart is independent of PI3-kinase/Akt
Reduced susceptibility to ischemia-induced arrhythmias in the preconditioned rat heart is independent of PI3-kinase/Akt
We examined the involvement of phosphatidylinositol 3-kinase (PI3K) and its effector protein ki nase B (Akt) in cardioprotective effects of ischemic preconditioning (PC) with parti...
Protection against ischemia-induced ventricular arrhythmias and myocardial dysfunction conferred by preconditioning in the rat heart: Involvement of mitochondrial K ATP channels and reactive oxygen species
Protection against ischemia-induced ventricular arrhythmias and myocardial dysfunction conferred by preconditioning in the rat heart: Involvement of mitochondrial K ATP channels and reactive oxygen species
a1_Ischemic preconditioning (I-PC) induced by brief episodes of ischemia and reperfusion (I/R) protects the heart against sustained I/R. Although activation of mitochondrial K ATP ...
Preconditioning Modulates Susceptibility to Ischemia-Induced Arrhythmias in the Rat Heart: The Role of a-Adrenergic Stimulation and K(ATP) Channels
Preconditioning Modulates Susceptibility to Ischemia-Induced Arrhythmias in the Rat Heart: The Role of a-Adrenergic Stimulation and K(ATP) Channels
a1_A new concept of cardioprotection based on the exploitation of endogenous mechanisms is known as ischemic preconditioning (IPC). It has been hypothesized that substances release...
MULTIDETECTOR COMPUTED TOMOGRAPHY IN BLUNT CHEST TRAUMA SINGLE TERTIARY CARE TRAUMA CENTRE EXPERIENCE.
MULTIDETECTOR COMPUTED TOMOGRAPHY IN BLUNT CHEST TRAUMA SINGLE TERTIARY CARE TRAUMA CENTRE EXPERIENCE.
Thoracic injuries are signicant causes of morbidity and mortality in trauma patients, second only to head injuries. In
addition to conventional radiography, multidetector computed...
Music listening to decrease intensity of agitated behaviour after severe acquired brain injury: An experimental multi-case study
Music listening to decrease intensity of agitated behaviour after severe acquired brain injury: An experimental multi-case study
Agitated behavior following a traumatic brain injury is frequent, placing patients and staff at risk of injury. Such behaviors decrease rehabilitation outcomes. This case study exp...
Neutrophil Lymphocyte Ratio: A Prognostic Indicator of Limb Survival in CLI Patients
Neutrophil Lymphocyte Ratio: A Prognostic Indicator of Limb Survival in CLI Patients
Aims and Objectives: This study was designed to evaluate the admission neutrophil-lymphocyte ratio in predicting the risk of amputation in critical limb ischemia patients who coul...