Protective effect of Anodonta cygnea hemolymph against acute kidney injury induced by gentamicin in rats

Background: Anodonta cygnea hemolymph has several pharmacological activities against inflammation, bacteria and tumor. The current study aimed to explore the efficacy of A. cygnea hemolymph against the renal toxicity induced by Gentamicin (GM) in rats. Methods: The animals were divided randomly into three groups (six per group): control, GM and A. cygnea. Tissues toxicity established after injection of GM daily for eight days at dose 100 mg/kg. Kidney functions, liver functions, oxidative stress markers and histopathology of tissues investigated in the study. Results: A. cygnea treated rats showed a significant decrease in urea, creatinine, uric acid, ALT, AST, GGT and MDA levels while GSH and CAT levels increased. The histopathological of liver and kidney investigation showed partial restoration of renal architecture. Conclusion: This study showed the A. cygnea potency in improving the biochemical and histopathological changes in the kidney of the rats following experimental induction of toxicity using Gentamycin.