COMPARATIVE CARDIAC REGENERATION: ZEBRAFISH VS. HUMAN HEART REPAIR MECHANISMS

Zebrafish(Danio rerio) can regenerate their hearts, completely after being injured, they have become an important model organism for research on cardiovascular regeneration. Through the proliferation and dedifferentiation of cardiomyocytes, and additional contributions of other cell types such as epicardial cells, endothelial cells, and fibroblasts.Zebrafish may repair significant cardiac injury, in contrast to mammals or humans whose hearts have limited regeneration capacity. Wnt/β-catenin, Notch and Hippo signaling are some of the molecular pathways involved in this regeneration process that coordinate the reactivation of cardiomyocytes, proliferation, and the development of new blood vessels. Comparative studies show how Zebrafish and mammals differ greatly in their ability to repair the heart, highlighting how Zebrafish research may help or guide us in regenerative medicine treatments for human heart disease. This analysis looks at the molecular and cellular processes that underlie the betterment of human life threatened by heart surgeries.