IMMUNOEXPRESSION OF VEGF IN ENDOMETRIAL CARCINOMA AND ITS HISTOPATHOLOGICAL CORRELATION

AIM OF THE STUDY: The aim of this study is to study the spectrum of Histopathology of Endometrial carcinoma with special reference to Immunohistochemical expression of VEGF in Endometrial carcinoma. OBJECTIVES: 1. To analyse the spectrum of Histopathological features of Endometrial carcinoma. 2. To Correlate the expression of VEGF in Histopathological types of Endometrial carcinoma and its targeted therapy. Methods : In this study histopathological types and immunohistochemical expression of VEGF in 32 cases of Endometrial carcinoma was observed for a period of one year. Result : Out of 32 cases 20 cases are of Type I endometrial carcinoma ( 12 cases of well differentiated and 8 cases of moderately differentiated histological type) and 12 cases of Type II endometrial carcinoma ( 8 cases of uterine papillary serous type , 3 of clear cell type and 1 case of carcinosarcoma ). The period of study was one year. Based on intensity of staining the percentage of cells were analysed and scoring was given from 0 - 3+ Conclusion: VEGF staining is increased in subset of aggressive endometrial carcinoma and appears to play regulatory roles in endometrial carcinoma angiogenesis. The observation in my study open up new perspective including novel markers that, combined together may be useful in patient screening for endometrial carcinoma aggressiveness. The combination of antivascular 3 therapy with Docetaxel is proved to be highly efcacious.