Evaluation of Antiarthritic Activity of Cordyline Fruticosa in Arthritic Rat Model

A persistent inflammatory process that causes joint injury and deformity, dysfunction, and and sometimes even death is a hallmark of rheumatoid arthritis , a systemic Autoimmune disorder. Rheumatoid arthritis (RA) is a systemic, autoimmune multisystem illness. that manifests as Pain, synovial membrane inflammation, peripheral joint inflammation, morning stiffness, and tissue deterioration, and reduced joint range of motion. Cordyline fruticose L also known as cordyline terminalis L belonging from family Agavaceae is commonly referred to as "good luck plant" and "Ti plant. Several different chemicals were found in C. fruticosa, including cholestane glycosides, polyphenols, flavonoids, glucofructan, tannins, alkaloids, steroidal saponins, and phytosterols, according to a phytochemical analysis. Pharmacological studies show that the plant has antimicrobial, antioxidative, and therapeutic properties related to stomach cancer. Following an examination of the literature, plant material was selected, collected, and authenticated. The collected plant material was dried and extracted with methanol as the solvent. The obtained methanolic extract underwent phytochemical study and GC-MS analysis to identify bioactive components. Pharmacological evaluations were carried out both in vitro and in vivo. Protein denaturation assays were used to determine in-vitro anti-inflammatory effects, which included the inhibition of egg albumin and bovine serum albumin. The in vivo anti-arthritic activity was assessed utilizing the Complete Freund's Adjuvant induced arthritis and formaldehyde-induced arthritis models. Various physical, biochemical, haematological, and histological characteristics were assessed, and the results were statistically analysed. The potency of cordyline fruticosa extract in methanol in formaldehyde induced arthritis as well as in complete Freund’s adjuvant rats has shown its excellent anti-arthritic activity. It has shown remarkable reduction in joint inflammation, arthritic scores, and paw edema in a dose-dependent fashion. These findings support the use of Cordyline fruticosa to treat inflammatory conditions and show that it can be used as a safe and effective alternative to arthritis treatment.