Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
FcγR polymorphisms: Implications for function, disease susceptibility and immunotherapy
View through CrossRef
Abstract: Leukocyte Fcγ receptors (FcγR) confer potent cellular effector functions to the specificity of IgG. FcγR‐induced leukocyte functions, including antibody‐dependent cellular cytotoxicity, phagocytosis, superoxide generation, degranulation, cytokine production and regulation of antibody production, are essential for host defense and immune regulation. The efficacy of IgG‐induced FcγR function displays inter‐individual heterogeneity due to genetic polymorphisms of three FcγR subclasses, FcγRIIa (CD32a), FcγRIIIa (CD16a), and FcγRIIIb (CD16b). FcγR polymorphisms have been associated with infectious and autoimmune disease, or with disease severity. FcγR polymorphisms may furthermore serve as markers for therapeutic efficacy and side‐effects of treatment with monoclonal antibodies. In this review, FcγR function and the relevance of FcγR polymorphisms as prognostic markers for inflammatory disease and antibody‐based immunotherapy are discussed.
Title: FcγR polymorphisms: Implications for function, disease susceptibility and immunotherapy
Description:
Abstract: Leukocyte Fcγ receptors (FcγR) confer potent cellular effector functions to the specificity of IgG.
FcγR‐induced leukocyte functions, including antibody‐dependent cellular cytotoxicity, phagocytosis, superoxide generation, degranulation, cytokine production and regulation of antibody production, are essential for host defense and immune regulation.
The efficacy of IgG‐induced FcγR function displays inter‐individual heterogeneity due to genetic polymorphisms of three FcγR subclasses, FcγRIIa (CD32a), FcγRIIIa (CD16a), and FcγRIIIb (CD16b).
FcγR polymorphisms have been associated with infectious and autoimmune disease, or with disease severity.
FcγR polymorphisms may furthermore serve as markers for therapeutic efficacy and side‐effects of treatment with monoclonal antibodies.
In this review, FcγR function and the relevance of FcγR polymorphisms as prognostic markers for inflammatory disease and antibody‐based immunotherapy are discussed.
Related Results
Reactive Oxygen Intermediates Enhance Fcγ Receptor Signaling and Amplify Phagocytic Capacity
Reactive Oxygen Intermediates Enhance Fcγ Receptor Signaling and Amplify Phagocytic Capacity
AbstractReceptors for the Fc region of IgG (FcγR) mediate internalization of opsonized particles by human neutrophils (PMN) and mononuclear phagocytes. Cross-linking of FcγR leads ...
Activation of Fc Gamma Receptor-Dependent Responses to Therapeutic Antibodies By Nurse like Cells Requires PI3Kdelta
Activation of Fc Gamma Receptor-Dependent Responses to Therapeutic Antibodies By Nurse like Cells Requires PI3Kdelta
Abstract
There is a continued reliance on antibody therapies for treating chronic lymphocytic leukaemia (CLL). Whilst the inclusion of antibody therapies in many sta...
The Impact of IL28B Gene Polymorphisms on Drug Responses
The Impact of IL28B Gene Polymorphisms on Drug Responses
To achieve high therapeutic efficacy in the patient, information on pharmacokinetics, pharmacodynamics, and pharmacogenetics is required. With the development of science and techno...
Aggregated Immunoglobulin Protects Immune T Cells from Suppression: Dependence on Isotype, Fc Portion, and Macrophage FcγR
Aggregated Immunoglobulin Protects Immune T Cells from Suppression: Dependence on Isotype, Fc Portion, and Macrophage FcγR
We determined the regulatory properties of heat‐aggregated immunoglobulins (HA‐Ig) that possess many activities of immune complexes (IC), such as binding and activation of cells vi...
Risk of Periodontitis in Systemic Lupus Erythematosus Is Associated with Fcγ Receptor Polymorphisms
Risk of Periodontitis in Systemic Lupus Erythematosus Is Associated with Fcγ Receptor Polymorphisms
Background: Leukocyte Fc receptors for immunoglobulin G (FcγR) play a major role in the handling of immune complexes and pathogens in systemic lupus erythematosus (SLE) and periodo...
Small Cell Lung Cancer and Tarlatamab: A Meta-Analysis of Clinical Trials
Small Cell Lung Cancer and Tarlatamab: A Meta-Analysis of Clinical Trials
Abstract
Introduction
Tarlatamab is a Delta-like ligand 3 (DLL3) -directed bispecific T-cell engager recently approved for use in patients with advanced small cell lung cancer (SCL...
Pathological response following neoadjuvant immunotherapy and imaging characteristics in dMMR/MSI-H locally advanced colorectal cancer
Pathological response following neoadjuvant immunotherapy and imaging characteristics in dMMR/MSI-H locally advanced colorectal cancer
BackgroundIn recent years, there has been significant research interest in immunotherapy for colorectal cancer (CRC). Specifically, immunotherapy has emerged as the primary treatme...
Human cytomegalovirus antagonizes activation of Fcγ receptors by distinct and synergizing modes of IgG manipulation
Human cytomegalovirus antagonizes activation of Fcγ receptors by distinct and synergizing modes of IgG manipulation
Human cytomegalovirus (HCMV) is endowed with multiple highly sophisticated immune evasion strategies. This includes the evasion from antibody mediated immune control by counteracti...